methyl (2'S,3R,5'S)-1'-acetyl-2-oxo-2'-[4-(trifluoromethyl)phenyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate

Base Information

Chemical Name:methyl (2'S,3R,5'S)-1'-acetyl-2-oxo-2'-[4-(trifluoromethyl)phenyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate
CAS No.:1352401-92-3
Molecular Formula:C₂₂H₁₉F₃N₂O₄
Molecular Weight:432.399
Hs Code.:

Synonyms:methyl (2'S,3R,5'S)-1'-acetyl-2-oxo-2'-[4-(trifluoromethyl)phenyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate

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Chemical Property of methyl (2'S,3R,5'S)-1'-acetyl-2-oxo-2'-[4-(trifluoromethyl)phenyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate

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Technology Process of methyl (2'S,3R,5'S)-1'-acetyl-2-oxo-2'-[4-(trifluoromethyl)phenyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate

There total 2 articles about methyl (2'S,3R,5'S)-1'-acetyl-2-oxo-2'-[4-(trifluoromethyl)phenyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₇F₃N₂O₃

: 108-24-7
acetic anhydride

: 1352401-92-3
methyl (2'S,3R,5'S)-1'-acetyl-2-oxo-2'-[4-(trifluoromethyl)phenyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2011.04.056

Reference yield:

: 1861-29-6
3-methylideneoxindole

: 286392-28-7
glycine methyl ester (4-trifluoromethylbenzaldehyde)imine

: 1352401-92-3
methyl (2'S,3R,5'S)-1'-acetyl-2-oxo-2'-[4-(trifluoromethyl)phenyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenylphosphino)ferrocene; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 2 h / 20 °C / Inert atmosphere

With tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenylphosphino)ferrocene; triethylamine; In dichloromethane;
DOI:10.1016/j.tet.2011.04.056