5′-O-dimethoxytrityl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine

Base Information

• Chemical Name: 5′-O-dimethoxytrityl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine
• CAS No.: 1542260-67-2
• Molecular Formula: C₃₈H₃₅N₅O₇
• Molecular Weight: 678.685

Synonyms:5′-O-dimethoxytrityl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine

Chemical Property of 5′-O-dimethoxytrityl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 5′-O-dimethoxytrityl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine

There total 9 articles about 5′-O-dimethoxytrityl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + 2′,3′,5′-trihydroxy-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N6-benzoyladenosine (1542260-64-9) → 5′-O-dimethoxytrityl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N6-benzoyladenosine (1542260-67-2)

Guidance literature:

With pyridine; at 0 ℃; for 4h;

Reference yield:

methyl ribofuranoside (1824-96-0,1824-97-1,3795-68-4,3795-69-5,4229-54-3,5531-18-0,7473-45-2,13039-63-9,13039-64-0,13039-65-1,13039-67-3,22416-73-5,22861-09-2,25129-51-5,52485-92-4,52689-55-1,52689-56-2,56607-40-0,72880-70-7,79083-42-4,86782-30-1,86782-31-2,89615-03-2,89673-67-6,89707-99-3,102045-32-9,135910-17-7) → 5′-O-dimethoxytrityl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N6-benzoyladenosine (1542260-67-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: water-d2 / 168 h / 110 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 48 h / 0 - 4 °C

3.1: hydrogen bromide / acetic acid / 0.5 h / 20 °C

4.1: pyridine / chloroform / 72 h / 20 °C

5.1: tin(IV) chloride / 1,2-dichloro-ethane / 0.25 h / 40 °C

5.2: 2.5 h / Reflux

6.1: water; sodium hydroxide; pyridine / methanol / 0.33 h / 0 °C

7.1: pyridine / 4 h / 0 °C

With pyridine; water; hydrogen bromide; water-d2; tin(IV) chloride; sodium hydroxide; In methanol; dichloromethane; chloroform; acetic acid; 1,2-dichloro-ethane;

Reference yield:

1-O-methyl-α/β-2,3,4,5,5′-pentadeuterium-D-ribofuranoside → 5′-O-dimethoxytrityl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N6-benzoyladenosine (1542260-67-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 48 h / 0 - 4 °C

2.1: hydrogen bromide / acetic acid / 0.5 h / 20 °C

3.1: pyridine / chloroform / 72 h / 20 °C

4.1: tin(IV) chloride / 1,2-dichloro-ethane / 0.25 h / 40 °C

4.2: 2.5 h / Reflux

5.1: water; sodium hydroxide; pyridine / methanol / 0.33 h / 0 °C

6.1: pyridine / 4 h / 0 °C

With pyridine; water; hydrogen bromide; tin(IV) chloride; sodium hydroxide; In methanol; dichloromethane; chloroform; acetic acid; 1,2-dichloro-ethane;

upstream raw materials:

4,4'-dimethoxytrityl chloride

2′,3′,5′-trihydroxy-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine

methyl ribofuranoside

N-benzoyladenine

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