benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate

Base Information

Chemical Name:benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate
CAS No.:106674-06-0
Molecular Formula:C₃₂H₃₃N₂O₁₁PS
Molecular Weight:684.661
Hs Code.:

benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate

Synonyms:benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate

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Chemical Property of benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate

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Technology Process of benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate

There total 1 articles about benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 106674-05-9
benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-hydroxy-7-(methyloxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate

: 5-(Diethoxy-phosphoryloxy)-4-methoxy-6-(toluene-4-sulfonyl)-3,6-dihydro-pyrrolo[3,2-e]indole-1,7-dicarboxylic acid 1-benzyl ester 7-methyl ester

: 106674-06-0
benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate

Guidance literature:: In diethyl ether; dichloromethane; at -78 ℃; for 48h;
DOI:10.1021/ja00243a026

Reference yield: 90.0%

: 106674-06-0
benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate

: 106674-08-2
benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate

Guidance literature:: With aluminum amalgam; In tetrahydrofuran; water; at 20 ℃; for 15h;
DOI:10.1021/ja00243a026

Reference yield:

: 106674-06-0
benzyl 3,6-dihydro-4-((diethoxyphosphinyl)oxy)-5-methoxy-7-(methoxycarbonyl)-6-((4-methylphenyl)sulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate

: 62497-62-5
6-aminocarbonyl-3,6,7,8-tetrahydro-5-hydroxy-4-methoxybenzo[1,2-b:4,3-b']dipyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Al-Hg / tetrahydrofuran

2: 90 percent / hydrogenolysis

3: 60 percent / Cu, i-Pr₂NEt, DMF / various solvent(s) / 130 °C

4: Et₃SiH-trifluoroacetic acid / CH₂Cl₂ / 0 - 20 °C

5: acetic acid

6: 68 percent / MeC(CH₂OH)3, KOH / methanol

7: 75 percent / 0.01 M aq. KOH / aq. KOH

With triethylsilane; potassium hydroxide; 2-(hydroxymethyl)-2-methylpropane-1,3-diol; aluminium amalgam; acetic acid; trifluoroacetic acid; copper; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; potassium hydroxide; dichloromethane;
DOI:10.1039/c39860001162