Technology Process of 4-((1R,2S)-2-(2-(4-(1H-tetrazol-1-yl)phenoxy)ethyl)cyclopropyl)piperidine
There total 11 articles about 4-((1R,2S)-2-(2-(4-(1H-tetrazol-1-yl)phenoxy)ethyl)cyclopropyl)piperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium;
In
ethanol;
at 20 ℃;
for 2h;
under 760.051 Torr;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C
2: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C
With
di-tert-butyl-diazodicarboxylate; hydrogen;
palladium 10% on activated carbon;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C
1.2: 1 h / -78 °C
2.1: hydrogen; quinoline / Lindlars catalyst / ethyl acetate / 0.67 h
3.1: diethylzinc / dichloromethane; diethyl ether / 0.17 h / -20 °C / Inert atmosphere
3.2: 0.17 h
3.3: 24 h / 0 °C
4.1: hydrogen / palladium(II) hydroxide / ethyl acetate; ethanol / 2585.81 Torr
4.2: 0 °C
4.3: 0.5 h / 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
6.1: triethylamine / dichloromethane / 20 °C
7.1: triethylamine / ethyl acetate / 4 h / Reflux
8.1: sodium hydrogencarbonate; dipotassium hydrogenphosphate / water; dimethyl sulfoxide; methanol / 7 h / 0 - 25 °C / pH 7 - 8
9.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C
10.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C
With
quinoline; hydrogenchloride; dipotassium hydrogenphosphate; n-butyllithium; di-tert-butyl-diazodicarboxylate; hydrogen; diethylzinc; sodium hydrogencarbonate; triethylamine;
palladium 10% on activated carbon; palladium(II) hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
