C₂₉H₂₉FNO₅P^(2-)*2Na⁽¹⁺⁾

Base Information

Chemical Name:C₂₉H₂₉FNO₅P^(2-)*2Na⁽¹⁺⁾
CAS No.:135426-86-7
Molecular Formula:C₂₉H₂₉FNO₅P*2Na
Molecular Weight:567.505
Hs Code.:

C<sub>29</sub>H<sub>29</sub>FNO<sub>5</sub>P<sup>(2-)</sup>*2Na<sup>(1+)</sup>

Synonyms:C₂₉H₂₉FNO₅P^(2-)*2Na⁽¹⁺⁾

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Chemical Property of C₂₉H₂₉FNO₅P^(2-)*2Na⁽¹⁺⁾

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Technology Process of C₂₉H₂₉FNO₅P^(2-)*2Na⁽¹⁺⁾

There total 12 articles about C₂₉H₂₉FNO₅P^(2-)*2Na⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-4-({(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

: 135426-86-7
C₂₉H₂₉FNO₅P^(2-)*2Na⁽¹⁺⁾

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 60 ℃; for 1.5h; Yield given;
DOI:10.1021/jm00113a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 135426-86-7
C₂₉H₂₉FNO₅P^(2-)*2Na⁽¹⁺⁾

Guidance literature:: Multi-step reaction with 11 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: 89 percent / oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

6: 93 percent / triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

7: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

8: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

9: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 25 min, 2.) THF, pentane, from -100 deg C to -78 deg C, 30 min

10: tetra-n-butylammonium fluoride, HOAc / tetrahydrofuran / 19 h / Ambient temperature

11: 1N aq. NaOH / dioxane / 1.5 h / 60 °C

With piperidine; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; copper diacetate; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); ammonium acetate; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; acetic acid; dimethyl sulfoxide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; acetic acid; benzene;
DOI:10.1021/jm00113a019

Reference yield:

: 137586-68-6
(E)-3-(2-Iodoethenyl)-4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo-[6,7]cyclohepta[1,2-b]pyridine

: 135426-86-7
C₂₉H₂₉FNO₅P^(2-)*2Na⁽¹⁺⁾

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 25 min, 2.) THF, pentane, from -100 deg C to -78 deg C, 30 min

2: tetra-n-butylammonium fluoride, HOAc / tetrahydrofuran / 19 h / Ambient temperature

3: 1N aq. NaOH / dioxane / 1.5 h / 60 °C

With sodium hydroxide; tetrabutyl ammonium fluoride; tert.-butyl lithium; acetic acid; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00113a019