(S)-1-((2R,6R)-tetrahydro-6-methyl-2H-pyran-2-yl)-3-(3,5-dimethoxyphenyl)propan-2-ol

Base Information

Chemical Name:(S)-1-((2R,6R)-tetrahydro-6-methyl-2H-pyran-2-yl)-3-(3,5-dimethoxyphenyl)propan-2-ol
CAS No.:1381766-17-1
Molecular Formula:C₁₇H₂₆O₄
Molecular Weight:294.391
Hs Code.:

Synonyms:(S)-1-((2R,6R)-tetrahydro-6-methyl-2H-pyran-2-yl)-3-(3,5-dimethoxyphenyl)propan-2-ol

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Chemical Property of (S)-1-((2R,6R)-tetrahydro-6-methyl-2H-pyran-2-yl)-3-(3,5-dimethoxyphenyl)propan-2-ol

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Technology Process of (S)-1-((2R,6R)-tetrahydro-6-methyl-2H-pyran-2-yl)-3-(3,5-dimethoxyphenyl)propan-2-ol

There total 6 articles about (S)-1-((2R,6R)-tetrahydro-6-methyl-2H-pyran-2-yl)-3-(3,5-dimethoxyphenyl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: C₂₄H₂₉NO₇

: 1381766-17-1
(S)-1-((2R,6R)-tetrahydro-6-methyl-2H-pyran-2-yl)-3-(3,5-dimethoxyphenyl)propan-2-ol

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jo300805n

Reference yield:

: 1381766-13-7
(S)-2-((2-(3,5-dimethoxybenzyl)-1,3-dithian-2-yl)methyl)oxirane

: 1381766-17-1
(S)-1-((2R,6R)-tetrahydro-6-methyl-2H-pyran-2-yl)-3-(3,5-dimethoxyphenyl)propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide / tetrahydrofuran / -30 °C

2: iodine; calcium carbonate / tetrahydrofuran; water / 0.5 h / 0 °C

3: acetic acid; tetramethylammonium triacetoxyborohydride / acetonitrile / 12 h / -30 °C

4: triethylsilane; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.5 h / 0 °C

5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

6: potassium carbonate / methanol / 1 h / 20 °C

With triethylsilane; copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; di-isopropyl azodicarboxylate; iodine; potassium carbonate; acetic acid; triphenylphosphine; calcium carbonate; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 5: Mitsunobu reaction;
DOI:10.1021/jo300805n

Reference yield:

: 1381766-14-8
(R)-1-(2-(3,5-dimethoxybenzyl)-1,3-dithian-2-yl)-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

: 1381766-17-1
(S)-1-((2R,6R)-tetrahydro-6-methyl-2H-pyran-2-yl)-3-(3,5-dimethoxyphenyl)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: iodine; calcium carbonate / tetrahydrofuran; water / 0.5 h / 0 °C

2: acetic acid; tetramethylammonium triacetoxyborohydride / acetonitrile / 12 h / -30 °C

3: triethylsilane; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.5 h / 0 °C

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

5: potassium carbonate / methanol / 1 h / 20 °C

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; di-isopropyl azodicarboxylate; iodine; potassium carbonate; acetic acid; triphenylphosphine; calcium carbonate; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 4: Mitsunobu reaction;
DOI:10.1021/jo300805n