4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester
CAS No.:1187522-67-3
Molecular Formula:C₂₆H₂₈N₄O₂
Molecular Weight:428.534
Hs Code.:

Synonyms:4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester

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Chemical Property of 4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester

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Technology Process of 4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester

There total 1 articles about 4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187522-66-2
4-[4-(4-(benzyloxycarbonyl)piperazin-1-yl)phenyl]-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester

: 1187522-67-3
4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester

Guidance literature:: 4-[4-(4-(benzyloxycarbonyl)piperazin-1-yl)phenyl]-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 18.08h;

With sodium carbonate; In 1,4-dioxane; dichloromethane; water; pH=7 - 8;

Reference yield:

: 62058-13-3
trans-4-aminoadamantan-1-ol

: 32315-10-9
bis(trichloromethyl) carbonate

: 1187522-67-3
4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester

: trans-4-{4-[4-(5-hydroxyadamantan-2-ylcarbamoyl)-3,4-dihydro-2H-quinoxalin-1-yl]phenyl}piperazine-1-carboxylic acid benzyl ester

Guidance literature:: bis(trichloromethyl) carbonate; 4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester; With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

trans-4-aminoadamantan-1-ol; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1187522-67-3
4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester

: trans-4-aminoadamantane-1-carboxylic acid amide hydrochloride

: trans-4-{4-[4-(5-carbamoyladamantan-2-ylcarbamoyl)-3,4-dihydro-2H-quinoxalin-1-yl]phenyl}piperazine-1-carboxylic acid benzyl ester

Guidance literature:: bis(trichloromethyl) carbonate; 4-[4-(3,4-dihydro-2H-quinoxalin-1-yl)phenyl]piperazine-1-carboxylic acid benzyl ester; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

trans-4-aminoadamantane-1-carboxylic acid amide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;