2-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-phenyl-4-(trifluoro methyl)nicotinonitrile

Base Information

Chemical Name:2-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-phenyl-4-(trifluoro methyl)nicotinonitrile
CAS No.:1582270-77-6
Molecular Formula:C₂₂H₁₂ClF₄N₅O
Molecular Weight:473.817
Hs Code.:

Synonyms:2-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-phenyl-4-(trifluoro methyl)nicotinonitrile

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Chemical Property of 2-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-phenyl-4-(trifluoro methyl)nicotinonitrile

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Technology Process of 2-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-phenyl-4-(trifluoro methyl)nicotinonitrile

There total 3 articles about 2-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-phenyl-4-(trifluoro methyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 85862-85-7
4-azido-2-chloro-1-fluorobenzene

: 1336913-39-3
6-phenyl-2-(prop-2-yn-1-yloxy)-4-(trifluoromethyl)nicotinonitrile

: 1582270-77-6
2-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-phenyl-4-(trifluoro methyl)nicotinonitrile

Guidance literature:: 6-phenyl-2-(prop-2-yn-1-yloxy)-4-(trifluoromethyl)nicotinonitrile; With copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 0.5h;

4-azido-2-chloro-1-fluorobenzene; In tetrahydrofuran; for 12h;
DOI:10.2174/1570178610666131118223356

Reference yield:

: 326-06-7
1-Phenyl-4,4,4-trifluorobutane-1,3-dione

: 1582270-77-6
2-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-phenyl-4-(trifluoro methyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine / ethanol / Reflux

2.1: potassium carbonate; sodium iodide / acetone / 20 °C

3.1: copper(l) iodide / tetrahydrofuran / 0.5 h / 20 °C

3.2: 12 h

With piperidine; copper(l) iodide; potassium carbonate; sodium iodide; In tetrahydrofuran; ethanol; acetone;
DOI:10.2174/1570178610666131118223356

Reference yield:

: 3335-44-2
2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 1582270-77-6
2-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-phenyl-4-(trifluoro methyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; sodium iodide / acetone / 20 °C

2.1: copper(l) iodide / tetrahydrofuran / 0.5 h / 20 °C

2.2: 12 h

With copper(l) iodide; potassium carbonate; sodium iodide; In tetrahydrofuran; acetone;
DOI:10.2174/1570178610666131118223356