2-[3-fluoro-4'-(N-hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-5-(N-hydroxy)amidine

Base Information

Chemical Name:2-[3-fluoro-4'-(N-hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-5-(N-hydroxy)amidine
CAS No.:851340-61-9
Molecular Formula:C₂₁H₁₇FN₆O₂
Molecular Weight:404.403
Hs Code.:

Synonyms:2-[3-fluoro-4'-(N-hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-5-(N-hydroxy)amidine

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Chemical Property of 2-[3-fluoro-4'-(N-hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-5-(N-hydroxy)amidine

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Technology Process of 2-[3-fluoro-4'-(N-hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-5-(N-hydroxy)amidine

There total 4 articles about 2-[3-fluoro-4'-(N-hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-5-(N-hydroxy)amidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126747-14-6
4-cyanophenylboronic acid

: 851340-61-9
2-[3-fluoro-4'-(N-hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-5-(N-hydroxy)amidine

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / Na₂CO₃ / tetrakis(triphenylphosphine)palladium / toluene; H₂O; methanol / 12 h / 80 °C

2: 90 percent / sodium hydrogen sulfite / dimethylformamide / Heating

3: 98 percent / hydroxylamine hydrochloride; potassium t-butoxide / dimethylsulfoxide / 20 °C

With hydroxylamine hydrochloride; potassium tert-butylate; sodium carbonate; sodium hydrogensulfite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2005.07.024

Reference yield:

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 851340-61-9
2-[3-fluoro-4'-(N-hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-5-(N-hydroxy)amidine

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / Na₂CO₃ / tetrakis(triphenylphosphine)palladium / toluene; H₂O; methanol / 12 h / 80 °C

2: 90 percent / sodium hydrogen sulfite / dimethylformamide / Heating

3: 98 percent / hydroxylamine hydrochloride; potassium t-butoxide / dimethylsulfoxide / 20 °C

With hydroxylamine hydrochloride; potassium tert-butylate; sodium carbonate; sodium hydrogensulfite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2005.07.024

Reference yield:

: 869767-75-9
3'-fluoro-4'-formyl-[1,1'-biphenyl]-4-carbonitrile

: 851340-61-9
2-[3-fluoro-4'-(N-hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-5-(N-hydroxy)amidine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / sodium hydrogen sulfite / dimethylformamide / Heating

2: 98 percent / hydroxylamine hydrochloride; potassium t-butoxide / dimethylsulfoxide / 20 °C

With hydroxylamine hydrochloride; potassium tert-butylate; sodium hydrogensulfite; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.07.024