2-(4-(tert-butyl)-2-(1,3-dioxan-2-yl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole

Base Information

Chemical Name:2-(4-(tert-butyl)-2-(1,3-dioxan-2-yl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole
CAS No.:1242157-08-9
Molecular Formula:C₁₉H₂₇NO₃
Molecular Weight:317.428
Hs Code.:

Synonyms:2-(4-(tert-butyl)-2-(1,3-dioxan-2-yl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole

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Chemical Property of 2-(4-(tert-butyl)-2-(1,3-dioxan-2-yl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole

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Technology Process of 2-(4-(tert-butyl)-2-(1,3-dioxan-2-yl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole

There total 5 articles about 2-(4-(tert-butyl)-2-(1,3-dioxan-2-yl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1242157-07-8
5-tert-butyl-2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-benzaldehyde

: 504-63-2
trimethyleneglycol

: 1242157-08-9
2-(4-(tert-butyl)-2-(1,3-dioxan-2-yl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole

Guidance literature:: With pyridinium p-toluenesulfonate; In toluene; Reflux;
DOI:10.1021/acsmedchemlett.0c00249

Reference yield:

: 438481-01-7
4-(tert-butyl)-N-(1-hydroxy-2-methylpropan-2-yl)benzamide

: 1242157-08-9
2-(4-(tert-butyl)-2-(1,3-dioxan-2-yl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 1 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 - -20 °C / Inert atmosphere

2.2: 2.25 h / -78 - 20 °C

3.1: pyridinium p-toluenesulfonate / toluene / Reflux

With n-butyllithium; thionyl chloride; pyridinium p-toluenesulfonate; In tetrahydrofuran; hexane; toluene;

Reference yield:

: 150943-13-8
2-(4-tert-butyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 1242157-08-9
2-(4-(tert-butyl)-2-(1,3-dioxan-2-yl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 - -20 °C / Inert atmosphere

1.2: 2.25 h / -78 - 20 °C

2.1: pyridinium p-toluenesulfonate / toluene / Reflux

With n-butyllithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; hexane; toluene;