benzyl 2-(5-(tert-butoxycarbonyl)pentylamino)ethylcarbamate

Base Information

• Chemical Name: benzyl 2-(5-(tert-butoxycarbonyl)pentylamino)ethylcarbamate
• CAS No.: 1353744-95-2
• Molecular Formula: C₂₀H₃₂N₂O₄
• Molecular Weight: 364.485
• Mol file: 1353744-95-2.mol

Synonyms:benzyl 2-(5-(tert-butoxycarbonyl)pentylamino)ethylcarbamate

Chemical Property of benzyl 2-(5-(tert-butoxycarbonyl)pentylamino)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of benzyl 2-(5-(tert-butoxycarbonyl)pentylamino)ethylcarbamate

There total 4 articles about benzyl 2-(5-(tert-butoxycarbonyl)pentylamino)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-2-iodo-ethylamine (68373-12-6) + 6-aminohexanoic acid tert-butyl ester (5514-98-7) → benzyl 2-(5-(tert-butoxycarbonyl)pentylamino)ethylcarbamate (1353744-95-2)

Guidance literature:

6-aminohexanoic acid tert-butyl ester; With potassium carbonate; In acetonitrile; for 0.166667h; Inert atmosphere; Reflux;

N-benzyloxycarbonyl-2-iodo-ethylamine; In acetonitrile; for 18h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2011.11.017

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → benzyl 2-(5-(tert-butoxycarbonyl)pentylamino)ethylcarbamate (1353744-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 0.17 h / Inert atmosphere; Reflux

3.2: 18 h / Inert atmosphere; Reflux

With 1H-imidazole; iodine; potassium carbonate; triphenylphosphine; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2011.11.017

Reference yield:

tert-butyl 6-(((benzyloxy)carbonyl)amino)hexanoate (158141-67-4) → benzyl 2-(5-(tert-butoxycarbonyl)pentylamino)ethylcarbamate (1353744-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 1 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / acetonitrile / 0.17 h / Inert atmosphere; Reflux

2.2: 18 h / Inert atmosphere; Reflux

With palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In methanol; acetonitrile;

DOI:10.1016/j.tet.2011.11.017

upstream raw materials:

6-(benzyloxycarbonylamino)hexanoic acid

N-benzyloxycarbonyl-2-iodo-ethylamine

6-aminohexanoic acid tert-butyl ester

benzyl chloroformate