6-(4-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)nicotinonitrile

Base Information

Chemical Name:6-(4-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)nicotinonitrile
CAS No.:1620827-97-5
Molecular Formula:C₂₀H₁₅F₄N₇O
Molecular Weight:445.379
Hs Code.:

Synonyms:6-(4-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)nicotinonitrile

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Chemical Property of 6-(4-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)nicotinonitrile

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Technology Process of 6-(4-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)nicotinonitrile

There total 4 articles about 6-(4-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1139703-59-5
2-azido-5-cyanopyridine

: 1620829-14-2
(4S,6S)-4-(5-ethynyl-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1620827-97-5
6-(4-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)nicotinonitrile

Guidance literature:: With copper (I) trifluoromethane sulfonate benzene; In toluene; at 20 ℃; for 96h; Inert atmosphere;

Reference yield:

: 1432511-74-4
(4S,6S)-4-(2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1620827-97-5
6-(4-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)nicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluorormethanesulfonic acid / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

1.2: 3 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 5.5 h / 65 °C / Inert atmosphere; Sealed tube

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 1 h / 0 °C

4.1: copper (I) trifluoromethane sulfonate benzene / toluene / 96 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper (I) trifluoromethane sulfonate benzene; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1620829-13-1
(4S,6S)-4-(2-fluoro-5-((trimethylsilyl)ethynyl)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1620827-97-5
6-(4-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 1 h / 0 °C

2: copper (I) trifluoromethane sulfonate benzene / toluene / 96 h / 20 °C / Inert atmosphere

With copper (I) trifluoromethane sulfonate benzene; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; toluene;