(1S,2E,4S)-1-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-4-phenylbut-2-ene-1,4-diol

Base Information

Chemical Name:(1S,2E,4S)-1-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-4-phenylbut-2-ene-1,4-diol
CAS No.:914248-53-6
Molecular Formula:C₁₈H₂₆O₆
Molecular Weight:338.401
Hs Code.:

Synonyms:(1S,2E,4S)-1-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-4-phenylbut-2-ene-1,4-diol

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Chemical Property of (1S,2E,4S)-1-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-4-phenylbut-2-ene-1,4-diol

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Technology Process of (1S,2E,4S)-1-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-4-phenylbut-2-ene-1,4-diol

There total 5 articles about (1S,2E,4S)-1-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-4-phenylbut-2-ene-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 914248-43-4
(1R,4S)-4-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-4-hydroxy-1-phenylbut-2-ynyl acetate

: 914248-53-6
(1S,2E,4S)-1-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-4-phenylbut-2-ene-1,4-diol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1021/ol0616539

Reference yield:

: 4187-87-5,61317-73-5,64937-86-6,64599-56-0
1-phenylprop-2-yn-1-ol

: 914248-53-6
(1S,2E,4S)-1-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-4-phenylbut-2-ene-1,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc triflate; (+)-N-methylephedrine; Et₃N / toluene / 0.5 h / 20 °C

1.2: 86 percent / toluene / 4 h / 20 °C

2.1: 87 percent / LiAlH₄ / tetrahydrofuran / 15 h / 20 °C

With lithium aluminium tetrahydride; zinc trifluoromethanesulfonate; (+)-N-methylephedrine; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/ol0616539

Reference yield:

: 4187-87-5
1-Phenyl-2-propyn-1-ol

: 914248-53-6
(1S,2E,4S)-1-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-4-phenylbut-2-ene-1,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Novozym 435 / 60 °C

2.1: zinc triflate; (+)-N-methylephedrine; Et₃N / toluene / 0.5 h / 20 °C

2.2: 86 percent / toluene / 4 h / 20 °C

3.1: 87 percent / LiAlH₄ / tetrahydrofuran / 15 h / 20 °C

With lithium aluminium tetrahydride; Novozym 435; zinc trifluoromethanesulfonate; (+)-N-methylephedrine; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/ol0616539