1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarbonitrile

Base Information

• Chemical Name: 1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarbonitrile
• CAS No.: 97861-26-2
• Molecular Formula: C₂₇H₂₇ClF₂N₄
• Molecular Weight: 480.988

Synonyms:1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarbonitrile

Chemical Property of 1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarbonitrile

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarbonitrile

There total 3 articles about 1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-piperidone hydrochloride (41979-39-9) → 1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarbonitrile (97861-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / sodium carbonate, sodium iodide / dimethylformamide / 20 h / 75 - 90 °C

2: 1.) toluene, reflux, 2.5 h, 2.) toluene, 50 deg C

With sodium carbonate; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00150a011

Reference yield:

N-(3-chloropropyl)-4-fluoro-N-(4-fluorophenyl)benzenamine (80119-31-9) → 1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarbonitrile (97861-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / sodium carbonate, sodium iodide / dimethylformamide / 20 h / 75 - 90 °C

2: 1.) toluene, reflux, 2.5 h, 2.) toluene, 50 deg C

With sodium carbonate; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00150a011

Reference yield:

4-chloro-aniline (106-47-8) + 2-hydroxy-2-methylpropanenitrile (75-86-5) + 1-<3-propyl>-4-piperidinone (80119-57-9) → 1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarbonitrile (97861-26-2)

Guidance literature:

Multistep reaction; 1.) toluene, reflux, 2.5 h, 2.) toluene, 50 deg C;

DOI:10.1021/jm00150a011

upstream raw materials:

4-chloro-aniline

2-hydroxy-2-methylpropanenitrile

1-<3-propyl>-4-piperidinone

4-piperidone hydrochloride

Downstream raw materials:

1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarboxamide

8-<3-propyl>-1-(4-chlorophenyl)-1,3,8-triazaspiro<4.5>dec-2-en-4-one

8-<3-propyl>-1-(4-chlorophenyl)-1,3,8-triazaspiro<4.5>decan-4-one

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