N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-2-amino-6-chloropurine

Base Information

• Chemical Name: N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-2-amino-6-chloropurine
• CAS No.: 1454334-52-1
• Molecular Formula: C₂₉H₂₇ClF₃N₅O
• Molecular Weight: 554.014

Synonyms:N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-2-amino-6-chloropurine

Chemical Property of N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-2-amino-6-chloropurine

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Technology Process of N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-2-amino-6-chloropurine

There total 3 articles about N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-2-amino-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N9-[(3'-adamantan-1-yl)-4'-hydroxybenzyl]-2-amino-6-chloropurine (1454334-49-6) + 1-(bromomethyl)-2,3,4-trifluorobenzene (157911-55-2) → N9-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-2-amino-6-chloropurine (1454334-52-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.2174/157018012804586996

Reference yield:

4-hydroxybenzyl chloride (35421-08-0) → N9-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-2-amino-6-chloropurine (1454334-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; acetic acid / dichloromethane / 48 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With sulfuric acid; potassium carbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: |Friedel-Crafts Alkylation;

DOI:10.2174/157018012804586996

Reference yield:

1-adamanthanol (768-95-6) → N9-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-2-amino-6-chloropurine (1454334-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; acetic acid / dichloromethane / 48 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With sulfuric acid; potassium carbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: |Friedel-Crafts Alkylation;

DOI:10.2174/157018012804586996

upstream raw materials:

N₉-[(3'-adamantan-1-yl)-4'-hydroxybenzyl]-2-amino-6-chloropurine

1-(bromomethyl)-2,3,4-trifluorobenzene

4-hydroxybenzyl chloride

1-adamanthanol

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