(5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 246873-45-0
• Molecular Formula: C14H20 N2 O2
• Molecular Weight: 248.325
• Hs Code.: 2924299090
• Mol file: 246873-45-0.mol

Synonyms:Carbamicacid, (5-amino-2,3-dihydro-1H-inden-2-yl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property of (5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• PSA: 64.35000
• LogP: 3.23280

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 5-amino-2,3-dihydro-1H-inden-2-ylcarbamate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

There total 5 articles about (5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-nitro-indan-2-yl)-carbamic acid tert-butyl ester → (5-amino-indan-2-yl)-carbamic acid tert-butyl ester (246873-45-0)

Guidance literature:

palladium; In ethanol;

Reference yield:

5-nitro-2,3-dihydro-1H-inden-2-amine → (5-amino-indan-2-yl)-carbamic acid tert-butyl ester (246873-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.11.072

Reference yield:

2,3-dihydro-1H-inden-2-amine (2975-41-9) → (5-amino-indan-2-yl)-carbamic acid tert-butyl ester (246873-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid / -30 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran

With palladium 10% on activated carbon; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.11.072

upstream raw materials:

2,3-dihydro-1H-inden-2-amine

di-tert-butyl dicarbonate

Downstream raw materials:

C₂₆H₃₀N₂O₄

C₂₂H₂₈N₂O₃

tert-Butyl 5-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-2,3-dihydro-1H-inden-2-ylcarbamate