1-[4-(Aminomethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone

Base Information

Chemical Name:1-[4-(Aminomethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone
CAS No.:634461-23-7
Molecular Formula:C₂₃H₂₉F₃N₆O
Molecular Weight:462.518
Hs Code.:

Synonyms:1-[4-(Aminomethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone

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Chemical Property of 1-[4-(Aminomethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone

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Technology Process of 1-[4-(Aminomethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone

There total 2 articles about 1-[4-(Aminomethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 634469-50-4
1-[2-[4-(2-Pyrazinyl)-1-piperazinyl]acetyl]-4-[3-(trifluoromethyl)phenyl]-4-piperidinecarbonitrile

: 634461-23-7
1-[4-(Aminomethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone

Guidance literature:: With ammonia; hydrogen; nickel; In methanol; water; at 20 ℃; for 16h; under 760.051 Torr; Product distribution / selectivity;

Reference yield:

: 634469-57-1
tert-butyl [1-[2-[4-(2-pyrazinyl)-1-piperazinyl]acetyl]-4-[3-(trifluoromethyl)phenyl]-4-piperidinyl]methylcarbamate

: 634461-23-7
1-[4-(Aminomethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone

Guidance literature:: tert-butyl [1-[2-[4-(2-pyrazinyl)-1-piperazinyl]acetyl]-4-[3-(trifluoromethyl)phenyl]-4-piperidinyl]methylcarbamate; With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; for 4h;

With potassium carbonate; In water; Product distribution / selectivity;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 634461-23-7
1-[4-(Aminomethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone

: 1-[4-[(dimethylamino)methyl]-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone

Guidance literature:: formaldehyd; 1-[4-(Aminomethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-2-[4-(2-pyrazinyl)-1-piperazinyl]-1-ethanone; With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; water; at 20 ℃;

With sodium hydroxide; In water; at 20 ℃; pH=9;