(S)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate

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Chemical Name:(S)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate
CAS No.:1218932-37-6
Molecular Formula:C₂₆H₂₆F₂N₂O₆S
Molecular Weight:532.565
Hs Code.:

Synonyms:(S)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate

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Chemical Property of (S)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate

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Technology Process of (S)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate

There total 1 articles about (S)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 942475-01-6
2′,4′-difluoro-biphenyl-4-sulfonylchloride

: 158325-89-4
(S)-methyl 2-(3-aminophenyl)-2-(tert-butoxycarbonylamino)acetate

: 1218932-37-6
(S)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate

Guidance literature:: 2′,4′-difluoro-biphenyl-4-sulfonylchloride; (S)-methyl 2-(3-aminophenyl)-2-(tert-butoxycarbonylamino)acetate; With pyridine; dmap; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water; for 0.5h;

Reference yield: 70.0%

: 1218932-37-6
(S)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate

: 1218932-38-7
(S)-tert-butyl 1-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)-2-hydroxyethylcarbamate

Guidance literature:: (S)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate; With lithium aluminium tetrahydride; In tetrahydrofuran; at -10 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran;