tert-butyl 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate

Base Information

Chemical Name:tert-butyl 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate
CAS No.:1263265-09-3
Molecular Formula:C₃₁H₄₅N₃O₅S
Molecular Weight:571.781
Hs Code.:

Synonyms:tert-butyl 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate

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Chemical Property of tert-butyl 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate

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Technology Process of tert-butyl 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate

There total 5 articles about tert-butyl 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1263265-08-2
(2-ethylthiazol-4-yl)(9-(4-(2-hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

: 1263265-09-3
tert-butyl 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate

Guidance literature:: With N-benzyl-trimethylammonium hydroxide; triethylamine; In water; acetonitrile; at 20 ℃; for 4h;

Reference yield:

: 769124-05-2
2-ethylthiazole-4-carboxylic acid

: 1263265-09-3
tert-butyl 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C / Inert atmosphere

2: dichloromethane / 22 h / 20 °C

3: caesium carbonate / 1-methyl-pyrrolidin-2-one / 22 h / 75 °C / Inert atmosphere

4: triethylamine; N-benzyl-trimethylammonium hydroxide / acetonitrile; water / 4 h / 20 °C

With N-benzyl-trimethylammonium hydroxide; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1263265-05-9
tert-butyl 4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

: 1263265-09-3
tert-butyl 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 22 h / 20 °C

2: caesium carbonate / 1-methyl-pyrrolidin-2-one / 22 h / 75 °C / Inert atmosphere

3: triethylamine; N-benzyl-trimethylammonium hydroxide / acetonitrile; water / 4 h / 20 °C

With N-benzyl-trimethylammonium hydroxide; caesium carbonate; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetonitrile;