(2R,2'S)-2-cyclohexyl-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]ethyl phenyl sulfone

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Chemical Name:(2R,2'S)-2-cyclohexyl-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]ethyl phenyl sulfone
CAS No.:218933-97-2
Molecular Formula:C₂₀H₃₂N₂O₃S
Molecular Weight:380.552
Hs Code.:

Synonyms:(2R,2'S)-2-cyclohexyl-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]ethyl phenyl sulfone

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Chemical Property of (2R,2'S)-2-cyclohexyl-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]ethyl phenyl sulfone

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Technology Process of (2R,2'S)-2-cyclohexyl-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]ethyl phenyl sulfone

There total 1 articles about (2R,2'S)-2-cyclohexyl-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]ethyl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112863-50-0
(E)-2-cyclohexyl-1-ethenyl phenyl sulfone

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 218933-97-2
(2R,2'S)-2-cyclohexyl-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]ethyl phenyl sulfone

: (2S,2'S)-2-cyclohexyl-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]ethyl phenyl sulfone

Guidance literature:: With ytterbium(III) triflate; In tetrahydrofuran; for 72h; Yield given; Yields of byproduct given; Heating;
DOI:10.1002/(sici)1521-3773(19990115)38:1/2<195::aid-anie195>3.0.co;2-6

Reference yield:

: 218933-97-2
(2R,2'S)-2-cyclohexyl-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]ethyl phenyl sulfone

: (R)-2-(tert-butoxycarbonylamino)-2-cyclohexylethyl phenyl sulfone

Guidance literature:: Multi-step reaction with 2 steps

1: BH₃*THF / tetrahydrofuran / 5 h / Heating

2: 2.13 g / Et₃N / methanol / 48 h / 20 °C

With borane-THF; triethylamine; In tetrahydrofuran; methanol; 1: Reduction / 2: Acylation;
DOI:10.1002/(sici)1099-0690(200003)2000:6<879::aid-ejoc879>3.0.co;2-e