3,7-Dichloro-6-methoxy-1-benzothiophene-2-carbonyl chloride

Base Information

• Chemical Name: 3,7-Dichloro-6-methoxy-1-benzothiophene-2-carbonyl chloride
• CAS No.: 34576-80-2
• Molecular Formula: C10H5 Cl3 O2 S
• Molecular Weight: 295.57
• Hs Code.: 2934999090
• European Community (EC) Number: 679-377-4
• DSSTox Substance ID: DTXSID60562891
• Wikidata: Q82447183
• Mol file: 34576-80-2.mol

Synonyms:34576-80-2;3,7-dichloro-6-methoxy-1-benzothiophene-2-carbonyl chloride;3,7-Dichloro-6-methoxybenzo[b]thiophene-2-carbonyl chloride;SCHEMBL8412444;DTXSID60562891;RYIXVDARTFRZDX-UHFFFAOYSA-N;3,7-Dichloro-6-Methoxy-Benzo[B]Thiophene-2-Carbonyl Chloride;MFCD02090812;AKOS005173154;SB67091;VS-04755

Chemical Property of 3,7-Dichloro-6-methoxy-1-benzothiophene-2-carbonyl chloride

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 174-175 °C(Solv: tetrahydrofuran (109-99-9))
• Refractive Index: 1.66
• Boiling Point: 408.3°Cat760mmHg
• Flash Point: 200.7°C
• PSA: 54.54000
• Density: 1.577g/cm³
• LogP: 4.59570
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 293.907584
• Heavy Atom Count: 16
• Complexity: 289

Purity/Quality:

98%Min ^*data from raw suppliers

3,7-Dichloro-6-methoxy-1-benzothiophene-2-carbonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C2=C(C=C1)C(=C(S2)C(=O)Cl)Cl)Cl

Technology Process of 3,7-Dichloro-6-methoxy-1-benzothiophene-2-carbonyl chloride

There total 3 articles about 3,7-Dichloro-6-methoxy-1-benzothiophene-2-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-Chloro-6-methoxy-benzo[b]thiophene-2-carbonyl chloride (75998-29-7) → 3,7-dichloro-6-methoxybenzothiophene-2-carbonyl chloride (34576-80-2)

Guidance literature:

With chlorine; In chloroform; for 1.25h; Ambient temperature;

DOI:10.1021/jm00083a023

Reference yield:

3-chloro-4-methoxycinnamic acid (58236-76-3,220353-69-5) → 3,7-dichloro-6-methoxybenzothiophene-2-carbonyl chloride (34576-80-2)

Guidance literature:

With pyridine; thionyl chloride; In N,N-dimethyl-formamide;

DOI:10.1039/d0ob00300j

Reference yield:

→ 3,7-dichloro-6-methoxybenzothiophene-2-carbonyl chloride (34576-80-2)

Guidance literature:

aus /BRN= 510468/, SOCl2 in Ggw. von Pyridin;

upstream raw materials:

3-Chloro-6-methoxy-benzo[b]thiophene-2-carbonyl chloride

3-chloro-4-methoxycinnamic acid

Refernces

• 1、 -. "Telomerase inhibitors". . . Retrieved 2008/06/13.