(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

Base Information

Chemical Name:(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one
CAS No.:127650-68-4
Molecular Formula:C₃₃H₄₄O₄Si
Molecular Weight:532.795
Hs Code.:

Synonyms:(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

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Chemical Property of (2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

Chemical Property:

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Technology Process of (2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

There total 4 articles about (2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 101415-96-7,101470-76-2
(2RS,5RS,9SR,10RS)-9-hydroxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

: 58479-61-1
tert-butylchlorodiphenylsilane

: 127650-68-4
(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 50 ℃; for 12h;

Reference yield:

: 101415-95-6
2,2-Dimethyl-propionic acid (2S,5S,10R)-6,10-dimethyl-8-trimethylsilanyloxy-spiro[4.5]deca-6,8-dien-2-yl ester

: 127650-68-4
(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triphenyl phosphite ozonide, 2.) Et₃N, triphenylphosphine / 1.) CH₂Cl₂, -50 deg C, 8 h, 2.) CH₂Cl₂, ether, r.t., 5 h

2: 98 percent / imidazole / dimethylformamide / 12 h / 50 °C

With 1H-imidazole; triphenyl phosphite ozonide; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide;

Reference yield:

: 92463-07-5
(2RS,5RS,10SR)-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

: 127650-68-4
(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) DME, -18 deg C, 1 h, 2.) DME, r.t., 2 h

2: 1.) triphenyl phosphite ozonide, 2.) Et₃N, triphenylphosphine / 1.) CH₂Cl₂, -50 deg C, 8 h, 2.) CH₂Cl₂, ether, r.t., 5 h

3: 98 percent / imidazole / dimethylformamide / 12 h / 50 °C

With 1H-imidazole; triphenyl phosphite ozonide; triethylamine; triphenylphosphine; lithium diisopropyl amide; In N,N-dimethyl-formamide;