3-(2-(chloromethyl)pyridin-4-yl)-5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(2-(chloromethyl)pyridin-4-yl)-5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole
CAS No.:1243560-25-9
Molecular Formula:C₂₁H₂₀ClF₃N₄O
Molecular Weight:436.864
Hs Code.:

Synonyms:3-(2-(chloromethyl)pyridin-4-yl)-5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

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Chemical Property of 3-(2-(chloromethyl)pyridin-4-yl)-5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

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Technology Process of 3-(2-(chloromethyl)pyridin-4-yl)-5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

There total 5 articles about 3-(2-(chloromethyl)pyridin-4-yl)-5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1140507-92-1
4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)benzonitrile

: 1243560-25-9
3-(2-(chloromethyl)pyridin-4-yl)-5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / methanol / 7 h / Heating; Reflux

1.2: 0 °C / pH 2

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 18 h / 20 °C

3.1: pyridine / acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

4.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With pyridine; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 1140461-91-1
4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)benzoic acid

: 1243560-25-9
3-(2-(chloromethyl)pyridin-4-yl)-5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 18 h / 20 °C

2: pyridine / acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

3: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With pyridine; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

Reference yield:

: 67515-59-7
4-Fluoro-3-(trifluoromethyl)benzonitrile

: 1243560-25-9
3-(2-(chloromethyl)pyridin-4-yl)-5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere of nitrogen

2.1: sodium hydroxide / methanol / 7 h / Heating; Reflux

2.2: 0 °C / pH 2

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 18 h / 20 °C

4.1: pyridine / acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

5.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With pyridine; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;