3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2-chloro-4-fluorophenyl)pyrrole-2,5-dione

Base Information

Chemical Name:3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2-chloro-4-fluorophenyl)pyrrole-2,5-dione
CAS No.:905854-16-2
Molecular Formula:C₂₁H₁₄ClFN₂O₂
Molecular Weight:380.806
Hs Code.:

Synonyms:3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2-chloro-4-fluorophenyl)pyrrole-2,5-dione

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Chemical Property of 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2-chloro-4-fluorophenyl)pyrrole-2,5-dione

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Technology Process of 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2-chloro-4-fluorophenyl)pyrrole-2,5-dione

There total 7 articles about 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2-chloro-4-fluorophenyl)pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 345264-02-0
(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

: 306937-35-9
2-chloro-4-fluorophenylacetamide

: 905854-16-2
3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2-chloro-4-fluorophenyl)pyrrole-2,5-dione

Guidance literature:: (5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester; 2-chloro-4-fluorophenylacetamide; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; Product distribution / selectivity;

Reference yield:

: 124730-53-6
5,6-dihydro-4H-pyrrolo [3,2,1-ij]quinoline-1-carboxylic acid ethyl ester

: 905854-16-2
3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2-chloro-4-fluorophenyl)pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol / 2 h / Reflux

2.1: copper chromite / quinoline / 2 h / 185 °C

3.1: diethyl ether / 0 °C

3.2: -78 - 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C

With potassium tert-butylate; water; sodium hydroxide; In tetrahydrofuran; quinoline; diethyl ether; ethanol;

Reference yield:

: 152712-44-2
3-(3,4-dihydro-2H-quinolin-1-yl)-2-oxopropionic acid ethyl ester

: 905854-16-2
3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2-chloro-4-fluorophenyl)pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium chloride / 2-methoxy-ethanol / 6 h / 125 °C / Reflux

2.1: sodium hydroxide; water / ethanol / 2 h / Reflux

3.1: copper chromite / quinoline / 2 h / 185 °C

4.1: diethyl ether / 0 °C

4.2: -78 - 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C

With potassium tert-butylate; water; sodium hydroxide; magnesium chloride; In tetrahydrofuran; quinoline; diethyl ether; ethanol; 2-methoxy-ethanol;