(E)-3-[6-Methyl-1-oxy-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester

Base Information

• Chemical Name: (E)-3-[6-Methyl-1-oxy-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester
• CAS No.: 1027662-52-7
• Molecular Formula: C₂₄H₃₁NO₄
• Molecular Weight: 397.514
• Mol file: 1027662-52-7.mol

Synonyms:(E)-3-[6-Methyl-1-oxy-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester

Chemical Property of (E)-3-[6-Methyl-1-oxy-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-[6-Methyl-1-oxy-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester

There total 4 articles about (E)-3-[6-Methyl-1-oxy-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-[6-Methyl-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester (1026300-73-1) → (E)-3-[6-Methyl-1-oxy-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester (1027662-52-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 16.5h;

DOI:10.1021/jm00074a013

Reference yield:

3-hydroxy-2-hydroxymethyl-6-methylpyridine (42097-42-7) → (E)-3-[6-Methyl-1-oxy-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester (1027662-52-7)

Guidance literature:

Multi-step reaction with 4 steps

1: MnO₂ / CH₂Cl₂ / 6 h / Ambient temperature

2: K₂CO₃ / dimethylformamide / 1.5 h / 90 °C

3: toluene / 1 h / 50 °C

4: 50percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

With manganese(IV) oxide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00046a017

Reference yield:

6-Methyl-3-(8-phenyl-octyloxy)-pyridine-2-carbaldehyde (1026866-56-7) → (E)-3-[6-Methyl-1-oxy-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester (1027662-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 1 h / 50 °C

2: 50percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;

DOI:10.1021/jm00046a017

upstream raw materials:

(E)-3-[6-Methyl-3-(8-phenyl-octyloxy)-pyridin-2-yl]-acrylic acid methyl ester

3-hydroxy-2-hydroxymethyl-6-methylpyridine

3-hydroxy-6-methylpicolinaldehyde

6-Methyl-3-(8-phenyl-octyloxy)-pyridine-2-carbaldehyde

Downstream raw materials:

3-[6-((E)-2-Methoxycarbonyl-vinyl)-5-(8-phenyl-octyloxy)-pyridin-2-ylmethylsulfanylmethyl]-benzoic acid methyl ester