benzyl 3-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]propionate

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Chemical Name:benzyl 3-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]propionate
CAS No.:171051-05-1
Molecular Formula:C₃₃H₃₀N₄O₃
Molecular Weight:530.626
Hs Code.:

Synonyms:benzyl 3-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]propionate

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Chemical Property of benzyl 3-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]propionate

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Technology Process of benzyl 3-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]propionate

There total 11 articles about benzyl 3-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171050-45-6
3-[2-(2-Carboxymethyl-1-cyclohexenyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]-pyridine

: 100-51-6,185532-71-2
benzyl alcohol

: 18107-18-1
diazomethyl-trimethyl-silane

: 171051-05-1
benzyl 3-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]propionate

Guidance literature:: With thionyl chloride; In hexane; dichloromethane; at 0 ℃; for 5.3h;

Reference yield:

: 131185-06-3
3-(3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo<1,5-a>pyridine

: 171051-05-1
benzyl 3-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 8.5 h / 120 °C

2: sodium hydride / methanol; toluene / 3 h / 100 °C

3: thionyl chloride / hexane; dichloromethane / 5.3 h / 0 °C

With thionyl chloride; sodium hydride; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 171050-45-6
3-[2-(2-Carboxymethyl-1-cyclohexenyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]-pyridine

: 171051-05-1
benzyl 3-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenyl]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 2.5 h / 20 °C

2: tetrahydrofuran; acetonitrile; hexane / 3 h / 0 °C

3: 87.0 mg / 2,4,6-trimethylpyridine / 0.12 h / 180 - 185 °C

With 2,4,6-trimethyl-pyridine; thionyl chloride; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; 1: Substitution / 2: Acylation / 3: Rearrangement;
DOI:10.1016/S0968-0896(99)00258-8