(2R,5R,6R)-6-benzyloxymethoxy-5-ethyl-2-methoxyethoxymethoxyheptane-1,5-diol

Base Information

Chemical Name:(2R,5R,6R)-6-benzyloxymethoxy-5-ethyl-2-methoxyethoxymethoxyheptane-1,5-diol
CAS No.:96823-45-9
Molecular Formula:C₂₁H₃₆O₇
Molecular Weight:400.513
Hs Code.:

Synonyms:(2R,5R,6R)-6-benzyloxymethoxy-5-ethyl-2-methoxyethoxymethoxyheptane-1,5-diol

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Chemical Property of (2R,5R,6R)-6-benzyloxymethoxy-5-ethyl-2-methoxyethoxymethoxyheptane-1,5-diol

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Technology Process of (2R,5R,6R)-6-benzyloxymethoxy-5-ethyl-2-methoxyethoxymethoxyheptane-1,5-diol

There total 13 articles about (2R,5R,6R)-6-benzyloxymethoxy-5-ethyl-2-methoxyethoxymethoxyheptane-1,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 126394-47-6
(2S,3R,6R)-3-benzyloxy-2-benzyloxymethoxy-3-ethyl-7-(4-methoxybenzyloxy)-6-methoxyethoxymethoxyheptane

: 96823-45-9
(2R,5R,6R)-6-benzyloxymethoxy-5-ethyl-2-methoxyethoxymethoxyheptane-1,5-diol

: 96823-37-9
(2R,5R,6S)-5-benzyloxy-6-benzyloxymethoxy-5-ethyl-2-methoxyethoxymethoxyheptan-1-ol

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; for 2h; Ambient temperature;
DOI:10.1016/S0040-4039(00)98547-2

Reference yield: 50.0%

: 126394-47-6
(2S,3R,6R)-3-benzyloxy-2-benzyloxymethoxy-3-ethyl-7-(4-methoxybenzyloxy)-6-methoxyethoxymethoxyheptane

: 96823-45-9
(2R,5R,6R)-6-benzyloxymethoxy-5-ethyl-2-methoxyethoxymethoxyheptane-1,5-diol

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 2h; Ambient temperature;
DOI:10.1016/S0040-4039(00)98547-2

Reference yield:

: 96823-33-5
(S)-3-(4-methoxybenzyloxy)-2-methoxyethoxymethoxypropanal

: 96823-45-9
(2R,5R,6R)-6-benzyloxymethoxy-5-ethyl-2-methoxyethoxymethoxyheptane-1,5-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaH / 1) THF, DMF, 0 to 20 deg C, 2) THF, DMF, 0 deg C, 3.5 h then 16h

2: 93 percent / hydrogen / 10percent Pd/C / ethyl acetate / 1.5 h / Ambient temperature

3: 100 percent / tetrahydrofuran / 2 h / -78 °C

4: 1) NaH / 1) THF, DMF, RT, 2) THF, DMF, 60 deg C,

5: 11 percent / DDQ / benzene; H₂O / 3 h / Ambient temperature

With hydrogen; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; water; ethyl acetate; benzene;
DOI:10.1248/cpb.37.1705