diethyl 2-acetyl-6,7-diphenyl-1,2-dihydroisoquinoline-3,3-dicarboxylate

Base Information

Chemical Name:diethyl 2-acetyl-6,7-diphenyl-1,2-dihydroisoquinoline-3,3-dicarboxylate
CAS No.:1226509-63-2
Molecular Formula:C₂₉H₂₉NO₅
Molecular Weight:471.553
Hs Code.:

Synonyms:diethyl 2-acetyl-6,7-diphenyl-1,2-dihydroisoquinoline-3,3-dicarboxylate

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Chemical Property of diethyl 2-acetyl-6,7-diphenyl-1,2-dihydroisoquinoline-3,3-dicarboxylate

Chemical Property:

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Technology Process of diethyl 2-acetyl-6,7-diphenyl-1,2-dihydroisoquinoline-3,3-dicarboxylate

There total 3 articles about diethyl 2-acetyl-6,7-diphenyl-1,2-dihydroisoquinoline-3,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1226509-13-2
diethyl 2-acetyl-6,7-diiodo-1,2-dihydroisoquinoline-3,3-dicarboxylate

: 98-80-6
phenylboronic acid

: 1226509-63-2
diethyl 2-acetyl-6,7-diphenyl-1,2-dihydroisoquinoline-3,3-dicarboxylate

Guidance literature:: diethyl 2-acetyl-6,7-diiodo-1,2-dihydroisoquinoline-3,3-dicarboxylate; phenylboronic acid; With sodium carbonate; In tetrahydrofuran; water; toluene; at 70 ℃;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; water; toluene; at 70 ℃;
DOI:10.3987/COM-09-S(S)103

Reference yield:

: 423756-29-0
1,2-bis-bromomethyl-4,5-diiodo-benzene

: 1226509-63-2
diethyl 2-acetyl-6,7-diphenyl-1,2-dihydroisoquinoline-3,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 24 h / 75 °C / Inert atmosphere

2.1: XPhos; sodium carbonate / tetrahydrofuran; toluene; water / 80 °C / Inert atmosphere

2.2: Inert atmosphere

With sodium carbonate; potassium carbonate; XPhos; In tetrahydrofuran; water; toluene; acetonitrile; 2.1: |Suzuki-Miyaura Coupling / 2.2: |Suzuki-Miyaura Coupling;
DOI:10.3987/COM-15-S(T)16

Reference yield:

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 1226509-63-2
diethyl 2-acetyl-6,7-diphenyl-1,2-dihydroisoquinoline-3,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 24 h / 75 °C / Inert atmosphere

2.1: XPhos; sodium carbonate / tetrahydrofuran; toluene; water / 80 °C / Inert atmosphere

2.2: Inert atmosphere

With sodium carbonate; potassium carbonate; XPhos; In tetrahydrofuran; water; toluene; acetonitrile; 2.1: |Suzuki-Miyaura Coupling / 2.2: |Suzuki-Miyaura Coupling;
DOI:10.3987/COM-15-S(T)16