N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

Base Information

Chemical Name:N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester
CAS No.:264921-81-5
Molecular Formula:C₃₆H₅₂N₄O₉
Molecular Weight:684.83
Hs Code.:

Synonyms:N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

Suppliers and Price of N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

There total 10 articles about N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 3978-80-1
Boc-Tyr-OH

: 264921-80-4
N-[1-(2'-amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

: 264921-81-5
N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 14h;
DOI:10.1021/jo991288h

Reference yield:

: 78158-90-4
(5R)-5-<(triphenylmethoxy)methyl>-γ-butyrolactone

: 264921-81-5
N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: (i-Pr)2NLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 3.5 h / -78 - -40 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 70 percent / Na₂SO₄; H₂O / tetrahydrofuran / -78 - 0 °C

3.1: 87 percent / HCl / methanol / 2 h / 20 °C

4.1: 91 percent / Et₃N; DMAP / CH₂Cl₂ / 14 h / 20 °C

5.1: 82 percent / NaN₃ / dimethylformamide / 5 h / 65 °C

6.1: 70 percent / Me₃Al / hexane; 1,2-dichloro-ethane / 24 h / Heating

7.1: 93 percent / diethyl ether

8.1: 90 percent / H₂ / Pd/C / methanol / 760.05 Torr

9.1: 72 percent / EDCI; HOBt / dimethylformamide / 14 h / 0 - 20 °C

With hydrogenchloride; dmap; sodium azide; hydrogen; trimethylaluminum; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1.1: Alkylation / 1.2: Alkylation / 2.1: Isomerization / 2.2: Hydrolysis / 3.1: Hydrolysis / 4.1: Tosylation / 5.1: Substitution / 6.1: Ring cleavage / 7.1: Esterification / 8.1: Reduction / 9.1: Condensation;
DOI:10.1021/jo991288h

Reference yield:

: 3303-55-7
L-Phe-Leu

: 264921-81-5
N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(R)-hydroxy-1(R)-methyl)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / Me₃Al / hexane; 1,2-dichloro-ethane / 24 h / Heating

2: 93 percent / diethyl ether

3: 90 percent / H₂ / Pd/C / methanol / 760.05 Torr

4: 72 percent / EDCI; HOBt / dimethylformamide / 14 h / 0 - 20 °C

With hydrogen; trimethylaluminum; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; diethyl ether; hexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: Ring cleavage / 2: Esterification / 3: Reduction / 4: Condensation;
DOI:10.1021/jo991288h