N-((S)-1-Carboxy-2-phenyl-ethyl)-succinamic acid allyl ester

Base Information

• Chemical Name: N-((S)-1-Carboxy-2-phenyl-ethyl)-succinamic acid allyl ester
• CAS No.: 169267-68-9
• Molecular Formula: C₁₆H₁₉NO₅
• Molecular Weight: 305.331
• Mol file: 169267-68-9.mol

Synonyms:N-((S)-1-Carboxy-2-phenyl-ethyl)-succinamic acid allyl ester

Chemical Property of N-((S)-1-Carboxy-2-phenyl-ethyl)-succinamic acid allyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-((S)-1-Carboxy-2-phenyl-ethyl)-succinamic acid allyl ester

There total 2 articles about N-((S)-1-Carboxy-2-phenyl-ethyl)-succinamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(allyloxy)-4-oxobutanoic acid (3882-09-5) → N-((S)-1-Carboxy-2-phenyl-ethyl)-succinamic acid allyl ester (169267-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2, DMF / CH₂Cl₂ / 2 h

2: Na₂CO₃, H₂O

With oxalyl dichloride; water; sodium carbonate; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1002/(SICI)1521-3765(19990104)5:1<79::AID-CHEM79>3.0.CO;2-W

Reference yield:

4-(allyloxy)-4-oxobutanoic acid (3882-09-5) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N-((S)-1-Carboxy-2-phenyl-ethyl)-succinamic acid allyl ester (169267-68-9)

Guidance literature:

With oxalyl dichloride; sodium carbonate; N,N-dimethyl-formamide; Yield given. Multistep reaction; 1.) CH₂Cl₂;

DOI:10.1016/0040-4039(95)00494-W

Reference yield: 72.0%

2.6-diaminopyridine (141-86-6) + N-((S)-1-Carboxy-2-phenyl-ethyl)-succinamic acid allyl ester (169267-68-9) → (rac)-Prop-2-enyl-4-benzyl-3,6-dioxo-11-amino-12,2,5,-diaza-1(1,3)-benzanonaphane-9-carboxylate (169267-69-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/0040-4039(95)00494-W

upstream raw materials:

4-(allyloxy)-4-oxobutanoic acid

L-phenylalanine

Downstream raw materials:

(rac)-Prop-2-enyl-4-benzyl-3,6-dioxo-11-amino-12,2,5,-diaza-1(1,3)-benzanonaphane-9-carboxylate

N-{1-[6-(2-{4'-[4-(tert-Butoxycarbonylamino-methyl)-phenoxymethyl]-biphenyl-4-yl}-acetylamino)-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-succinamic acid allyl ester