4-({3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)morpholine

Base Information

Chemical Name:4-({3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)morpholine
CAS No.:1359026-92-8
Molecular Formula:C₂₅H₂₄F₃N₅O₄S
Molecular Weight:547.558
Hs Code.:

Synonyms:4-({3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)morpholine

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Chemical Property of 4-({3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)morpholine

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Technology Process of 4-({3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)morpholine

There total 6 articles about 4-({3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1359026-91-7
3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonic acid

: 1359026-92-8
4-({3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)morpholine

Guidance literature:: 3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonic acid; With thionyl chloride; N,N-dimethyl-formamide; at 20 ℃; for 3h; Cooling with ice;

morpholine; at 20 ℃; for 4h; Cooling with ice;

Reference yield:

: 1356997-87-9
4-iodo-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

: 1359026-92-8
4-({3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)morpholine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 65 °C

2.1: potassium hydroxide; ethanol / 3 h / Reflux

3.1: acetic acid; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 22 h / 20 - 85 °C / Inert atmosphere

4.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice

4.2: 4 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; ethanol; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; HATU; potassium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: 1359029-69-8
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carboxylic acid

: 1359026-92-8
4-({3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 22 h / 20 - 85 °C / Inert atmosphere

2.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice

2.2: 4 h / 20 °C / Cooling with ice

With thionyl chloride; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; HATU; In N,N-dimethyl-formamide;