ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Base Information

Chemical Name:ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate
CAS No.:1591994-64-7
Molecular Formula:C₂₃H₁₆F₅NO₅
Molecular Weight:481.376
Hs Code.:

Synonyms:ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

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Chemical Property of ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

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Technology Process of ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

There total 4 articles about ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1591994-08-9
ethyl 2-(prop-2-ynyloxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

: 247092-11-1
2,4-difluoro-benzaldehyde oxime

: 1591994-64-7
ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Guidance literature:: With sodium hypochlorite; triethylamine; In dichloromethane; water; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2014.02.069

Reference yield:

: 90-02-8
salicylaldehyde

: 1591994-64-7
ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine / ethanol / 5 h / Reflux

2.1: potassium carbonate; potassium iodide / acetone / 0.5 h / 20 °C

2.2: 3 h / Reflux

3.1: triethylamine; sodium hypochlorite / dichloromethane; water / 0 - 20 °C

With piperidine; sodium hypochlorite; potassium carbonate; triethylamine; potassium iodide; In ethanol; dichloromethane; water; acetone;
DOI:10.1016/j.bmcl.2014.02.069

Reference yield:

: 1021155-28-1
ethyl 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate

: 1591994-64-7
ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; potassium iodide / acetone / 0.5 h / 20 °C

1.2: 3 h / Reflux

2.1: triethylamine; sodium hypochlorite / dichloromethane; water / 0 - 20 °C

With sodium hypochlorite; potassium carbonate; triethylamine; potassium iodide; In dichloromethane; water; acetone;
DOI:10.1016/j.bmcl.2014.02.069