2-(4-Chloro-phenoxymethyl)-1H-benzoimidazole

Base Information

• Chemical Name: 2-(4-Chloro-phenoxymethyl)-1H-benzoimidazole
• CAS No.: 3156-18-1
• Molecular Formula: C14H11 Cl N2 O
• Molecular Weight: 258.707
• Hs Code.: 2933990090
• Mol file: 3156-18-1.mol

Synonyms:Benzimidazole,2-[(p-chlorophenoxy)methyl]- (7CI,8CI); 2-(4-Chlorophenoxymethyl)benzimidazole;2-(4'-Chlorophenoxymethyl)benzimidazole;2-[(4-Chlorophenoxy)methyl]-1H-benzimidazole; NSC 697073

Chemical Property of 2-(4-Chloro-phenoxymethyl)-1H-benzoimidazole

Chemical Property:

• Melting Point: 174 °C
• Boiling Point: 496.6±25.0 °C(Predicted)
• PKA: 11.34±0.10(Predicted)
• PSA: 37.91000
• Density: 1.349±0.06 g/cm3(Predicted)
• LogP: 3.79530

Purity/Quality:

99% ^*data from raw suppliers

2-(4-CHLORO-PHENOXYMETHYL)-1H-BENZOIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Chloro-phenoxymethyl)-1H-benzoimidazole

There total 6 articles about 2-(4-Chloro-phenoxymethyl)-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloromethyl-1H-benzimidazole (4857-04-9) + 4-chloro-phenol (106-48-9,82344-39-6) → 1-(benzimidazol-2-ylmethoxy)-4-chlorobenzene (3156-18-1)

Guidance literature:

4-chloro-phenol; With potassium carbonate; In water; N,N-dimethyl-formamide; for 1h;

2-chloromethyl-1H-benzimidazole; With potassium iodide; In water; N,N-dimethyl-formamide; for 6h; Reflux;

Reference yield: 68.0%

4-Chlorophenoxyacetic acid (122-88-3) + 1,2-diamino-benzene (95-54-5) → 1-(benzimidazol-2-ylmethoxy)-4-chlorobenzene (3156-18-1)

Guidance literature:

With hydrogenchloride; In water; Inert atmosphere; Reflux;

Reference yield: 60.0%

N-(p-chlorophenoxyacetyl)phenylalanine methyl ester (79397-26-5) + 1,2-diamino-benzene (95-54-5) → 2-(2-benzimidazolyl)-1-(4-chlorophenoxyacetyl)phenethylamine + 1-(benzimidazol-2-ylmethoxy)-4-chlorobenzene (3156-18-1)

Guidance literature:

at 180 ℃; for 1h;

upstream raw materials:

4-Chlorophenoxyacetic acid

1,2-diamino-benzene

N-(p-chlorophenoxyacetyl)phenylalanine methyl ester

(4-chlorophenoxy)acetonitrile

Downstream raw materials:

4-{2-[2-(4-Chloro-phenoxymethyl)-benzoimidazol-1-yl]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

4-{3-[2-(4-Chloro-phenoxymethyl)-benzoimidazol-1-yl]-propyl}-piperidine-1-carboxylic acid tert-butyl ester

2-{2-[2-(4-Chloro-phenoxymethyl)-benzoimidazol-1-yl]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

2-(4-chlorophenoxymethyl)-1H-benzimidazole acetic acid hydrazide

Refernces

• 1、 Wu, Jiacheng,Zhao, Li,Zhao, Changqing,Wang, Zhiyuan,Gu, Haibin,Chen, Wuyong. "Synthesis and molecular structures of 1-hydroxyethyl-2-(p-substituted) phenoxymethyl benzimidazoles". . p. 974 - 980. Retrieved 2016/11/22.
• 2、 Wei, Tai-Bao,Hua, Mao-Tang,Shi, Hai-Xiong,Liu, Yong,Zhang, You-Ming. "Aza-Michael addition of acrylonitrile with 2-aryloxymethylbenzimidazole derivatives under microwave irradiation". scheme or table. p. 452 - 454. Retrieved 2010/12/24.