2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxycytidine

Base Information

Chemical Name:2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxycytidine
CAS No.:219618-97-0
Molecular Formula:C₄₇H₆₄N₄O₅Si₃
Molecular Weight:849.305
Hs Code.:

2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'-<N-(tert-butyldiphenylsilyl)oxyamino>-3'-deoxycytidine

Synonyms:2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxycytidine

Suppliers and Price of 2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxycytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxycytidine

Chemical Property:

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Technology Process of 2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxycytidine

There total 5 articles about 2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90813-54-0
2',5'-bis-O-tert-butyldimethylsilyl-3'-ketouridine

: 219618-97-0
2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxycytidine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / NH₂OH*HCl, pyridine / 0.33 h / Ambient temperature

2: 99 percent / 80 percent aq. TFA / 0.5 h / 0 °C

3: 92 percent / NaBH₄, AcOH / 2 h / 0 °C

4: 90 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

5: 1.) Et₃N, TPSCl, DMAP, 2.) NH₄OH / 1.) MeCN, RT, 2 h, 2.) MeCN, 3 h

With pyridine; 1H-imidazole; dmap; ammonium hydroxide; sodium tetrahydroborate; Triphenylsilyl chloride; hydroxylamine hydrochloride; acetic acid; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm980466g

Reference yield:

: 218967-30-7
1-<2-O-(tert-butyldimethylsilyl)-3-deoxy-3-(hydroxyimino)-β-D-erythro-pentofuranosyl>uracil

: 219618-97-0
2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NaBH₄, AcOH / 2 h / 0 °C

2: 90 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

3: 1.) Et₃N, TPSCl, DMAP, 2.) NH₄OH / 1.) MeCN, RT, 2 h, 2.) MeCN, 3 h

With 1H-imidazole; dmap; ammonium hydroxide; sodium tetrahydroborate; Triphenylsilyl chloride; acetic acid; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm980466g

Reference yield:

: 218967-53-4
2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3-(hydroxylamino)uridine

: 219618-97-0
2'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-3'--3'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 1.) Et₃N, TPSCl, DMAP, 2.) NH₄OH / 1.) MeCN, RT, 2 h, 2.) MeCN, 3 h

With 1H-imidazole; dmap; ammonium hydroxide; Triphenylsilyl chloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm980466g