(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenal

Base Information

Chemical Name:(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenal
CAS No.:144149-44-0
Molecular Formula:C₂₇H₂₉FN₂O
Molecular Weight:416.538
Hs Code.:

Synonyms:(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenal

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Chemical Property of (E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenal

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Technology Process of (E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenal

There total 5 articles about (E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 144149-10-0
(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol

: 144149-44-0
(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenal

Guidance literature:: With manganese(IV) oxide; In benzene; for 2h; Heating;
DOI:10.1021/jm00075a024

Reference yield:

: 2-(4-tert-butylbenzyl)cyclohexanone

: 144149-44-0
(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenal

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) diisopropylamine, n-BuLi / 1.) hexane, THF, -78 deg C, 45 min, 2.) hexane, THF, RT, overnight

2: 1.) NaOAc, 2.) aq. HCl / 1.) MeOH, from RT, overnight to reflux, 2 h, 2.) THF, reflux, 4 h

3: 100 percent / NaH / tetrahydrofuran / Ambient temperature

4: (i-Bu)2AlH / tetrahydrofuran; toluene / 0.5 h

5: 60 percent / MnO₂ / benzene / 2 h / Heating

With hydrogenchloride; manganese(IV) oxide; n-butyllithium; sodium acetate; sodium hydride; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; toluene; benzene;
DOI:10.1021/jm00075a024

Reference yield:

: 144147-77-3
6-(4-tert-butylbenzyl)-2-(2,2-dimethoxyacetyl)cyclohexanone

: 144149-44-0
(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenal

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaOAc, 2.) aq. HCl / 1.) MeOH, from RT, overnight to reflux, 2 h, 2.) THF, reflux, 4 h

2: 100 percent / NaH / tetrahydrofuran / Ambient temperature

3: (i-Bu)2AlH / tetrahydrofuran; toluene / 0.5 h

4: 60 percent / MnO₂ / benzene / 2 h / Heating

With hydrogenchloride; manganese(IV) oxide; sodium acetate; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; toluene; benzene;
DOI:10.1021/jm00075a024