(3-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)phenyl)methanol

Base Information

• Chemical Name: (3-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)phenyl)methanol
• CAS No.: 1251457-89-2
• Molecular Formula: C₁₈H₁₈F₃NO
• Molecular Weight: 321.342

Synonyms:(3-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)phenyl)methanol

Chemical Property of (3-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)phenyl)methanol

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Technology Process of (3-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)phenyl)methanol

There total 1 articles about (3-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl 5-(3-(hydroxymethyl)-5-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-1-ylcarbamate (1251457-88-1) → (3-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)phenyl)methanol (1251457-89-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 1h;

Reference yield: 42.1%

(3-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)phenyl)methanol (1251457-89-2) + 3-(trifluoromethyl)-2-pyridinecarboxaldehyde (131747-62-1) → (3-(trifluoromethyl)-5-((1-((3-(trifluoromethyl)pyridin-2-yl)methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)phenyl)methanol (1251457-64-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 35.7%

thiophene-2-sulfonyl chloride (16629-19-9) + (3-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)phenyl)methanol (1251457-89-2) → N-(5-(3-(hydroxymethyl)-5-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-1-yl)thiophene-2-sulfonamide (1251457-58-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h;

upstream raw materials:

benzyl 5-(3-(hydroxymethyl)-5-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-1-ylcarbamate

Downstream raw materials:

N-(5-(3-(hydroxymethyl)-5-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-1-yl)thiophene-2-sulfonamide

2,2,2-trifluoro-N-(5-(3-(hydroxymethyl)-5-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-1-yl)acetamide

(3-(trifluoromethyl)-5-((1-((3-(trifluoromethyl)pyridin-2-yl)methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)phenyl)methanol

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