(+/-)-2-[3-(benzhydryldimethylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

Base Information

Chemical Name:(+/-)-2-[3-(benzhydryldimethylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran
CAS No.:274676-34-5
Molecular Formula:C₂₄H₃₀O₂Si
Molecular Weight:378.587
Hs Code.:

Synonyms:(+/-)-2-[3-(benzhydryldimethylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

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Chemical Property of (+/-)-2-[3-(benzhydryldimethylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

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Technology Process of (+/-)-2-[3-(benzhydryldimethylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

There total 2 articles about (+/-)-2-[3-(benzhydryldimethylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 57188-99-5
3-butyn-2-yl tetrahydropyranyl ether

: 132455-95-9
(diphenylmethyl)dimethylchlorosilane

: 274676-34-5
(+/-)-2-[3-(benzhydryldimethylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

Guidance literature:: 3-butyn-2-yl tetrahydropyranyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

(diphenylmethyl)dimethylchlorosilane; In tetrahydrofuran; hexane; for 0.5h; Further stages.;
DOI:10.1021/ol005676d

Reference yield:

: 101-81-5
Diphenylmethane

: 274676-34-5
(+/-)-2-[3-(benzhydryldimethylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / hexane; diethyl ether / 48 h / Heating

1.2: 70 percent / hexane; diethyl ether / 4 h / -78 - 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / -78 °C

2.2: 88 percent / tetrahydrofuran; hexane / 0.5 h

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; 1.1: Metallation / 1.2: Substitution / 2.1: Metallation / 2.2: Substitution;
DOI:10.1021/ol005676d

Reference yield: 86.0%

: 274676-34-5
(+/-)-2-[3-(benzhydryldimethylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

: (+/-)-(Z)-1-benzhydryldimethylsilyl-1-buten-3-ol

Guidance literature:: (+/-)-2-[3-(benzhydryldimethylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran; With dimethylsulfide borane complex; cyclohexene; In tetrahydrofuran; at 0 - 22 ℃;

With acetic acid; In tetrahydrofuran; at 22 ℃; for 12h; Further stages.;
DOI:10.1021/ol005676d