1-[2-(3-Fluorophenyl)ethyl]piperazine 2HCl

Base Information

• Chemical Name: 1-[2-(3-Fluorophenyl)ethyl]piperazine 2HCl
• CAS No.: 188400-93-3
• Molecular Formula: C₁₂H₁₇FN₂
• Molecular Weight: 208.279
• Hs Code.: 2933599590
• Mol file: 188400-93-3.mol

Synonyms:1-[2-(3-fluorophenyl)ethyl]piperazine

Chemical Property of 1-[2-(3-Fluorophenyl)ethyl]piperazine 2HCl

Chemical Property:

• Boiling Point: 296.1±25.0 °C(Predicted)
• PKA: 9.20±0.10(Predicted)
• Density: 1.062±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

1-[2-(3-Fluorophenyl)ethyl]piperazinedihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[2-(3-Fluorophenyl)ethyl]piperazine 2HCl

There total 6 articles about 1-[2-(3-Fluorophenyl)ethyl]piperazine 2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-[2-(3-fluoro-phenyl)-ethyl]piperazine-1-carboxylic acid ethyl ester (862158-61-0) → 1-[2-(3-fluorophenyl)ethyl]piperazine (188400-93-3)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 12h; Heating;

DOI:10.1021/jo050464l

Reference yield: 85.0%

C17H25FN2O2 → 1-[2-(3-fluorophenyl)ethyl]piperazine (188400-93-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/jm501719e

Reference yield:

potassium carbonate (584-08-7) + 2-(3-fluorophenyl)acetaldehyde (75321-89-0) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-[2-(3-fluorophenyl)ethyl]piperazine (188400-93-3)

Guidance literature:

With formic acid; sodium cyanoborohydride; In methanol; acetic acid;

upstream raw materials:

4-[2-(3-fluoro-phenyl)-ethyl]piperazine-1-carboxylic acid ethyl ester

2-(3-fluorophenyl)ethanol

1-(2-bromoethyl)-3-fluorobenzene

(3-fluorophenyl)acetic acid

Downstream raw materials:

1-but-3-enyl-4-[2-(3-fluoro-phenyl)-ethyl]piperazine

L-775606

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