(2R)-2-(benzyl{2-[benzyl((1R)-2-{[bis(propan-2-yl)phosphanyl]oxy}-1-phenylethyl)amino]ethyl}amino)-2-phenylethyl bis(propan-2-yl)phosphinite

Base Information

• Chemical Name: (2R)-2-(benzyl{2-[benzyl((1R)-2-{[bis(propan-2-yl)phosphanyl]oxy}-1-phenylethyl)amino]ethyl}amino)-2-phenylethyl bis(propan-2-yl)phosphinite
• CAS No.: 1421593-20-5
• Molecular Formula: C₄₄H₆₂N₂O₂P₂
• Molecular Weight: 712.936
• Mol file: 1421593-20-5.mol

Synonyms:(2R)-2-(benzyl{2-[benzyl((1R)-2-{[bis(propan-2-yl)phosphanyl]oxy}-1-phenylethyl)amino]ethyl}amino)-2-phenylethyl bis(propan-2-yl)phosphinite

Chemical Property of (2R)-2-(benzyl{2-[benzyl((1R)-2-{[bis(propan-2-yl)phosphanyl]oxy}-1-phenylethyl)amino]ethyl}amino)-2-phenylethyl bis(propan-2-yl)phosphinite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-(benzyl{2-[benzyl((1R)-2-{[bis(propan-2-yl)phosphanyl]oxy}-1-phenylethyl)amino]ethyl}amino)-2-phenylethyl bis(propan-2-yl)phosphinite

There total 4 articles about (2R)-2-(benzyl{2-[benzyl((1R)-2-{[bis(propan-2-yl)phosphanyl]oxy}-1-phenylethyl)amino]ethyl}amino)-2-phenylethyl bis(propan-2-yl)phosphinite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

3-chloro-2,4-dimethylpentane (19174-61-9) + (2R)-2-[benzyl(2-{benzyl[(1R)-2-hydroxy-1-phenylethyl]amino}ethyl)amino]-2-phenylethan-1-ol (1421593-13-6) → (2R)-2-(benzyl{2-[benzyl((1R)-2-{[bis(propan-2-yl)phosphanyl]oxy}-1-phenylethyl)amino]ethyl}amino)-2-phenylethyl bis(propan-2-yl)phosphinite (1421593-20-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1055/s-0032-1317505

Reference yield:

(R)-phenylglycine (875-74-1) → (2R)-2-(benzyl{2-[benzyl((1R)-2-{[bis(propan-2-yl)phosphanyl]oxy}-1-phenylethyl)amino]ethyl}amino)-2-phenylethyl bis(propan-2-yl)phosphinite (1421593-20-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate; iodine / tetrahydrofuran / Inert atmosphere

2: sodium carbonate / 12 h / 110 °C / Inert atmosphere

3: sodium carbonate / 12 h / 110 °C / Inert atmosphere

4: triethylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; iodine; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-0032-1317505

Reference yield:

(R)-N-benzyl-2-phenylglycinol (14231-57-3) → (2R)-2-(benzyl{2-[benzyl((1R)-2-{[bis(propan-2-yl)phosphanyl]oxy}-1-phenylethyl)amino]ethyl}amino)-2-phenylethyl bis(propan-2-yl)phosphinite (1421593-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / 12 h / 110 °C / Inert atmosphere

2: triethylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere

With sodium carbonate; triethylamine; In dichloromethane;

DOI:10.1055/s-0032-1317505

upstream raw materials:

(R)-N-benzyl-2-phenylglycinol

3-chloro-2,4-dimethylpentane

(2R)-2-[benzyl(2-{benzyl[(1R)-2-hydroxy-1-phenylethyl]amino}ethyl)amino]-2-phenylethan-1-ol

D-2-phenylglycinol