ethyl (Z)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

Base Information

Chemical Name:ethyl (Z)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate
CAS No.:169113-46-6
Molecular Formula:C₂₂H₂₁Cl₂NO₄
Molecular Weight:434.319
Hs Code.:

Synonyms:ethyl (Z)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

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Chemical Property of ethyl (Z)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

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Technology Process of ethyl (Z)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

There total 7 articles about ethyl (Z)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: ethyl (3RS,5RS,αSR)-α-methanesulfonyloxy-7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetate

: 169113-46-6
ethyl (Z)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

: 169113-47-7
ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

Guidance literature:: With cesium propionate; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1248/cpb.50.53

Reference yield: 16.0%

: ethyl (3RS,5SR,αSR)-α-methanesulfonyloxy-7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetate

: 169113-46-6
ethyl (Z)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

: 169113-47-7
ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

Guidance literature:: With cesium propionate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;
DOI:10.1248/cpb.50.53

Reference yield:

: 63734-73-6,66647-16-3,68521-71-1,89886-73-7,93061-20-2,149884-11-7
ethyl (2S,3S)-3-carboxylate oxirane-2-carboxylic acid

: 169113-46-6
ethyl (Z)-[7-chloro-5-(2-chlorophenyl)-1-isopropyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / dichloromethylenedimethyliminium chloride; NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

2: 24 percent / K₂CO₃ / ethanol / 20 °C

3: 89 percent / Et₃N / ethyl acetate / 1 h

4: 38 percent / cesium propionate / dimethylformamide / 2 h / 80 °C

With cesium propionate; sodium hydrogencarbonate; dichloromethylenedimethyliminium chloride; potassium carbonate; triethylamine; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.50.53