9-chloro-6-(3-fluoro-4-methoxybenzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-one

Base Information

Chemical Name:9-chloro-6-(3-fluoro-4-methoxybenzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-one
CAS No.:1207516-24-2
Molecular Formula:C₂₅H₂₂ClFN₂O₂
Molecular Weight:436.913
Hs Code.:

Synonyms:9-chloro-6-(3-fluoro-4-methoxybenzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-one

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Chemical Property of 9-chloro-6-(3-fluoro-4-methoxybenzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-one

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Technology Process of 9-chloro-6-(3-fluoro-4-methoxybenzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-one

There total 1 articles about 9-chloro-6-(3-fluoro-4-methoxybenzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1207516-41-3
2-(6-chloro-1H-indol-3-yl)-3-hydroxy-5,5-dimethylcyclohex-2-en-1-one

: 452-14-2
2-(4-fluoro-3-methoxyphenyl)acetic acid

: 1207516-24-2
9-chloro-6-(3-fluoro-4-methoxybenzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-one

Guidance literature:: 2-(6-chloro-1H-indol-3-yl)-3-hydroxy-5,5-dimethylcyclohex-2-en-1-one; With zinc(II) chloride; In diethyl ether; dichloromethane; at 20 - 25 ℃; Inert atmosphere;

2-(4-fluoro-3-methoxyphenyl)acetic acid; With trifluoroacetic anhydride; In diethyl ether; nitromethane; dichloromethane; at 20 - 50 ℃; for 20h; Inert atmosphere;

With ammonium acetate; ammonia; In methanol; diethyl ether; nitromethane; dichloromethane; for 2h; Reflux; Inert atmosphere;

Reference yield: 20.0%

: 1207516-24-2
9-chloro-6-(3-fluoro-4-methoxybenzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-one

: 1207516-25-3
(1S)-9-chloro-6-(3-fluoro-4-methoxybenzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-ol

Guidance literature:: 9-chloro-6-(3-fluoro-4-methoxybenzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-one; With sodium tetrahydroborate; calcium hydride; D-tartaric acid; m-nitrobenzene boronic acid; In tetrahydrofuran; at 0 - 25 ℃; Ice bath; Inert atmosphere;

With methanol; In tetrahydrofuran; at 20 - 25 ℃; Inert atmosphere;