Ethyl 7-[[4-chlorophenyl] amino]-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

Base Information

• Chemical Name: Ethyl 7-[[4-chlorophenyl] amino]-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate
• CAS No.: 1321921-98-5
• Molecular Formula: C₂₁H₁₇ClFN₃O₅
• Molecular Weight: 445.834
• Mol file: 1321921-98-5.mol

Synonyms:Ethyl 7-[[4-chlorophenyl] amino]-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

Chemical Property of Ethyl 7-[[4-chlorophenyl] amino]-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Ethyl 7-[[4-chlorophenyl] amino]-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

There total 1 articles about Ethyl 7-[[4-chlorophenyl] amino]-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-aniline (106-47-8) + 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-nitro-4-oxo-3-quinolinecarboxylic acid ethyl ester (111453-55-5) → Ethyl 7-[[4-chlorophenyl] amino]-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate (1321921-98-5)

Guidance literature:

With pyridine; In dimethyl sulfoxide; at 70 ℃;

DOI:10.3390/molecules22010071 DOI:10.3390/molecules22050841

Reference yield:

Ethyl 7-[[4-chlorophenyl] amino]-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate (1321921-98-5) → 1-cyclopropyl-6-fluoro-8-nitro-4-oxo-7-(4-chloro-phenylamino)-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:

With hydrogenchloride; In ethanol; at 80 - 85 ℃;

DOI:10.3390/molecules22010071 DOI:10.3390/molecules22050841

Reference yield:

Ethyl 7-[[4-chlorophenyl] amino]-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate (1321921-98-5) → 3-[4-Chloro-phenyl]-9-cyclopropyl-4-fluoro-6-oxo-6,9-dihydro-3H-[1, 2, 3] triazolo[4,5-h]quinoline-7-carboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol / 80 - 85 °C

2.1: hydrogenchloride / water / 0.25 h / Cooling with ice

2.2: 25 °C

3.1: hydrogenchloride / water / 0.25 h / 0 - 5 °C

With hydrogenchloride; In ethanol; water;

DOI:10.3390/molecules22050841

upstream raw materials:

4-chloro-aniline

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-nitro-4-oxo-3-quinolinecarboxylic acid ethyl ester