(1R,2S)-1-Amino-2-(anilinomethyl)cyclopropane-1-carboxylic acid

Base Information

• Chemical Name: (1R,2S)-1-Amino-2-(anilinomethyl)cyclopropane-1-carboxylic acid
• CAS No.: 244233-42-9
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.244
• DSSTox Substance ID: DTXSID70440732
• Nikkaji Number: J1.160.940F
• Wikidata: Q82257118
• Mol file: 244233-42-9.mol

Synonyms:244233-42-9;(1R,2S)-1-Amino-2-(anilinomethyl)cyclopropane-1-carboxylic acid;DTXSID70440732;Cyclopropanecarboxylic acid, 1-amino-2-[(phenylamino)methyl]-, (1R,2S)- (9CI);(1R,2S)-1-Amino-2-(phenylaminomethyl)cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid,1-amino-2-[(phenylamino)methyl]-,(1R,2S)-(9ci)

Chemical Property of (1R,2S)-1-Amino-2-(anilinomethyl)cyclopropane-1-carboxylic acid

Chemical Property:

• PSA: 75.35000
• LogP: 1.67380
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 206.105527694
• Heavy Atom Count: 15
• Complexity: 251

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C1(C(=O)O)N)CNC2=CC=CC=C2
• Isomeric SMILES: C1[C@H]([C@]1(C(=O)O)N)CNC2=CC=CC=C2

Technology Process of (1R,2S)-1-Amino-2-(anilinomethyl)cyclopropane-1-carboxylic acid

There total 16 articles about (1R,2S)-1-Amino-2-(anilinomethyl)cyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(1R,3R,6S)-6-tert-butyl-5-methoxy-6-methyl-1-phenylaminomethyl-7-oxa-4-azaspiro[2.5]oct-4-en-8-one (565237-68-5) → (1R,2S)-1-amino-2-(phenylaminomethyl)cyclopropanecarboxylic acid (244233-42-9,244233-43-0,565237-95-8)

Guidance literature:

(1R,3R,6S)-6-tert-butyl-5-methoxy-6-methyl-1-phenylaminomethyl-7-oxa-4-azaspiro[2.5]oct-4-en-8-one; With trifluoroacetic acid; In water; acetonitrile; at 60 ℃; for 20h;

With sodium hydroxide; In 1,2-dimethoxyethane; water; at 90 ℃; for 120h;

DOI:10.1002/ejoc.200390179

Reference yield: 50.0%

(1S,3S,6S)-6-tert-butyl-5-methoxy-6-methyl-1-phenylaminomethyl-7-oxa-4-azaspiro[2.5]oct-4-en-8-one (565237-70-9) → (1S,2S)-1-amino-2-(phenylaminomethyl)cyclopropanecarboxylic acid (244233-42-9,244233-43-0,565237-95-8)

Guidance literature:

(1S,3S,6S)-6-tert-butyl-5-methoxy-6-methyl-1-phenylaminomethyl-7-oxa-4-azaspiro[2.5]oct-4-en-8-one; With trifluoroacetic acid; In water; acetonitrile; at 60 ℃; for 20h;

With sodium hydroxide; In 2-ethoxy-ethanol; water; at 90 ℃; for 120h;

DOI:10.1002/ejoc.200390179

Reference yield:

(1S,3R)-1-((1R,2S)-1-Amino-2-phenylaminomethyl-cyclopropanecarbonyloxy)-3-methoxymethyl-2,2,3-trimethyl-cyclopentanecarboxylic acid methyl ester → (1R,2R)-1-amino-2-(phenylaminomethyl)cyclopropanecarboxylic acid (244233-42-9,244233-43-0,565237-95-8)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 24h;

DOI:10.1002/(SICI)1099-0690(199908)1999:8<1967::AID-EJOC1967>3.0.CO;2-G

upstream raw materials:

(1R,3R,6S,8R)-11-methoxy-8-methoxymethyl-7,7,8-trimethyl-4-oxo-5-oxa-12-azadispiro[2.2.4.2]dodec-11-en-1-carbaldehyde

(1R,3R,6S,8R)-1-hydroxymethyl-11-methoxy-8-methoxymethyl-7,7,8-trimethyl-5-oxa-12-azadispiro[2.2.4.2]dodec-11-en-4-one

(1R,3R,6S,8R)-11-methoxy-8-methoxymethyl-7,7,8-trimethyl-1-phenylaminomethyl-5-oxa-12-azadispiro[2.2.4.2]dodec-11-en-4-one

(1R,3R,6S)-6-tert-butyl-5-methoxy-6-methyl-1-phenylaminomethyl-7-oxa-4-azaspiro[2.5]oct-4-en-8-one