1,3,5-trimethoxy-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene

Base Information

• Chemical Name: 1,3,5-trimethoxy-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene
• CAS No.: 434323-19-0
• Molecular Formula: C₂₄H₄₅O₁₂P₃
• Molecular Weight: 618.535
• Mol file: 434323-19-0.mol

Synonyms:1,3,5-trimethoxy-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene

Chemical Property of 1,3,5-trimethoxy-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,5-trimethoxy-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene

There total 2 articles about 1,3,5-trimethoxy-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,3,5-tris(bromomethyl)-2,4,6-(trimethoxy)benzene (434323-17-8) + triethyl phosphite (122-52-1) → 1,3,5-trimethoxy-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene (434323-19-0)

Guidance literature:

In toluene; at 120 ℃; for 3h;

DOI:10.1021/ol025739n

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) → 1,3,5-trimethoxy-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene (434323-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide; acetic acid / 80 °C

2: 110 °C

With hydrogen bromide; acetic acid; 2: |Michaelis-Arbuzov Synthesis;

DOI:10.1016/j.jorganchem.2017.12.028

Reference yield: 34.0%

5-nitro-2-thiophenecarboxaldehyde (4521-33-9) + 1,3,5-trimethoxy-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene (434323-19-0) → 1,3,5-trimethoxy-2,4,6-tris[2-(5-nitrothiophen-2-yl)-vinyl]benzene

Guidance literature:

1,3,5-trimethoxy-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 1h;

5-nitro-2-thiophenecarboxaldehyde; In tetrahydrofuran; at 20 ℃; for 12h; Further stages.;

DOI:10.1021/ol025739n

upstream raw materials:

1,3,5-tris(bromomethyl)-2,4,6-(trimethoxy)benzene

triethyl phosphite

1,2,3-trimethoxybenzene

Downstream raw materials:

1,3,5-trimethoxy-2,4,6-tris(p-cyanostyryl)benzene

1,3,5-trimethoxy-2,4,6-tris(p-formylstyryl)benzene