N-(4-CHLOROPHENYL)-2-[(5,7-DIMETHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)SULFANYL]ACETAMIDE

Base Information

• Chemical Name: N-(4-CHLOROPHENYL)-2-[(5,7-DIMETHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)SULFANYL]ACETAMIDE
• CAS No.: 212074-47-0
• Molecular Formula: C₁₅H₁₄ClN₅OS
• Molecular Weight: 347.828
• Mol file: 212074-47-0.mol

Synonyms:N-(4-chloro-phenyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-acetamide

Chemical Property of N-(4-CHLOROPHENYL)-2-[(5,7-DIMETHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)SULFANYL]ACETAMIDE

Chemical Property:

Purity/Quality:

N-(4-CHLOROPHENYL)-2-[(5,7-DIMETHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)SULFANYL]ACETAMIDE 95.00% ^*data from reagent suppliers

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Technology Process of N-(4-CHLOROPHENYL)-2-[(5,7-DIMETHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)SULFANYL]ACETAMIDE

There total 2 articles about N-(4-CHLOROPHENYL)-2-[(5,7-DIMETHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)SULFANYL]ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-aniline (106-47-8) + α-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-thio) acetic acid (56347-19-4) → N-(4-chloro-phenyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-acetamide (212074-47-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1526-4998(200003)56:3<218::AID-PS116>3.0.CO;2-9

Reference yield:

5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol (51646-17-4) → N-(4-chloro-phenyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-acetamide (212074-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaOH / H₂O / 0.5 h / Heating

1.2: 90 percent / H₂O / 5 h / Heating

2.1: DCC / dimethylformamide / 6 h / 20 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In water; N,N-dimethyl-formamide;

DOI:10.1002/hc.1075

Reference yield: 57.0%

N-(4-chloro-phenyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-acetamide (212074-47-0) → N-(4-chloro-phenyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonyl)-acetamide

Guidance literature:

With sodium tungstate; dihydrogen peroxide; In water; acetic acid; at 55 - 60 ℃; for 5h;

DOI:10.1002/hc.1075

upstream raw materials:

4-chloro-aniline

α-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-thio) acetic acid

5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol

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