(S)-5-[(Dimethyl-phenyl-silanyl)-methyl]-2-hydroxy-2-((Z)-7-trimethylsilanyl-hept-5-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

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Chemical Name:(S)-5-[(Dimethyl-phenyl-silanyl)-methyl]-2-hydroxy-2-((Z)-7-trimethylsilanyl-hept-5-enyl)-pyrrolidine-1-carboxylic acid benzyl ester
CAS No.:1026985-49-8
Molecular Formula:C₃₁H₄₇NO₃Si₂
Molecular Weight:537.89
Hs Code.:

Synonyms:(S)-5-[(Dimethyl-phenyl-silanyl)-methyl]-2-hydroxy-2-((Z)-7-trimethylsilanyl-hept-5-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

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Chemical Property of (S)-5-[(Dimethyl-phenyl-silanyl)-methyl]-2-hydroxy-2-((Z)-7-trimethylsilanyl-hept-5-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

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Technology Process of (S)-5-[(Dimethyl-phenyl-silanyl)-methyl]-2-hydroxy-2-((Z)-7-trimethylsilanyl-hept-5-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

There total 5 articles about (S)-5-[(Dimethyl-phenyl-silanyl)-methyl]-2-hydroxy-2-((Z)-7-trimethylsilanyl-hept-5-enyl)-pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72479-05-1
(S)-(-)-5-(Bromomethyl)-2-pyrrolidinone

: 1026985-49-8
(S)-5-[(Dimethyl-phenyl-silanyl)-methyl]-2-hydroxy-2-((Z)-7-trimethylsilanyl-hept-5-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / Li; CuCN / tetrahydrofuran / 19 h / -40 - -20 °C

2.1: 96 percent / KH / tetrahydrofuran / 0.92 h / 0 - 20 °C

3.1: t-BuLi / diethyl ether; pentane / 1.67 h / -78 - 20 °C

3.2: diethyl ether; pentane / 4 h / -78 - -20 °C

With tert.-butyl lithium; lithium; potassium hydride; In tetrahydrofuran; diethyl ether; pentane;
DOI:10.1021/jo0201070

Reference yield:

: 92121-08-9
7-trimethylsilanylhept-5-en-1-ol

: 1026985-49-8
(S)-5-[(Dimethyl-phenyl-silanyl)-methyl]-2-hydroxy-2-((Z)-7-trimethylsilanyl-hept-5-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / I₂; PPh₃; imidazole / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2.1: t-BuLi / diethyl ether; pentane / 1.67 h / -78 - 20 °C

2.2: diethyl ether; pentane / 4 h / -78 - -20 °C

With 1H-imidazole; iodine; tert.-butyl lithium; triphenylphosphine; In diethyl ether; dichloromethane; pentane;
DOI:10.1021/jo0201070

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1026985-49-8
(S)-5-[(Dimethyl-phenyl-silanyl)-methyl]-2-hydroxy-2-((Z)-7-trimethylsilanyl-hept-5-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / KH / tetrahydrofuran / 0.92 h / 0 - 20 °C

2.1: t-BuLi / diethyl ether; pentane / 1.67 h / -78 - 20 °C

2.2: diethyl ether; pentane / 4 h / -78 - -20 °C

With tert.-butyl lithium; potassium hydride; In tetrahydrofuran; diethyl ether; pentane;
DOI:10.1021/jo0201070