N-benzyl-3-[hydroxy(triphenylmethylimidazol-4-yl)methyl]pyrrolidin-2-one

Base Information

• Chemical Name: N-benzyl-3-[hydroxy(triphenylmethylimidazol-4-yl)methyl]pyrrolidin-2-one
• CAS No.: 639089-37-5
• Molecular Formula: C₃₄H₃₁N₃O₂
• Molecular Weight: 513.639
• Mol file: 639089-37-5.mol

Synonyms:N-benzyl-3-[hydroxy(triphenylmethylimidazol-4-yl)methyl]pyrrolidin-2-one

Chemical Property of N-benzyl-3-[hydroxy(triphenylmethylimidazol-4-yl)methyl]pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-benzyl-3-[hydroxy(triphenylmethylimidazol-4-yl)methyl]pyrrolidin-2-one

There total 1 articles about N-benzyl-3-[hydroxy(triphenylmethylimidazol-4-yl)methyl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-benzyl-2-pyrrolidone (5291-77-0) + (1-tritylimidazol-4-yl)carboxaldehyde (33016-47-6) → N-benzyl-3-[hydroxy(triphenylmethylimidazol-4-yl)methyl]pyrrolidin-2-one (639089-37-5)

Guidance literature:

1-benzyl-2-pyrrolidone; With n-butyllithium; In tetrahydrofuran; hexane; at -60 ℃; for 0.5h;

(1-tritylimidazol-4-yl)carboxaldehyde; In tetrahydrofuran; hexane; at -60 - 20 ℃;

DOI:10.1021/jm030905y

Reference yield:

N-benzyl-3-[hydroxy(triphenylmethylimidazol-4-yl)methyl]pyrrolidin-2-one (639089-37-5) → 1-benzyl-3-[chloro-(1-trityl-1H-imidazol-4-yl)-methyl]-pyrrolidin-2-one

Guidance literature:

With pyridine; trichlorophosphate; at 20 ℃; for 1h;

DOI:10.1021/jm030905y

Reference yield:

N-benzyl-3-[hydroxy(triphenylmethylimidazol-4-yl)methyl]pyrrolidin-2-one (639089-37-5) → N-benzyl-3-(triphenylmethylimidazol-4-ylmethylene)pyrrolidine

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃; pyridine / 1 h / 20 °C

2: DBU; pyridine / 3 h / 20 °C

3: LiAlH₄; H₂SO₄ / tetrahydrofuran / 1 h

With pyridine; lithium aluminium tetrahydride; sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In tetrahydrofuran;

DOI:10.1021/jm030905y

upstream raw materials:

1-benzyl-2-pyrrolidone

(1-tritylimidazol-4-yl)carboxaldehyde