(S)-3-(5-amino-6-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)pyridin-2-yl)-4-fluoro-N-isopropylbenzamide

Base Information

Chemical Name:(S)-3-(5-amino-6-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)pyridin-2-yl)-4-fluoro-N-isopropylbenzamide
CAS No.:1214241-26-5
Molecular Formula:C₂₈H₃₀FN₇O
Molecular Weight:499.591
Hs Code.:

Synonyms:(S)-3-(5-amino-6-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)pyridin-2-yl)-4-fluoro-N-isopropylbenzamide

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Chemical Property of (S)-3-(5-amino-6-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)pyridin-2-yl)-4-fluoro-N-isopropylbenzamide

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Technology Process of (S)-3-(5-amino-6-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)pyridin-2-yl)-4-fluoro-N-isopropylbenzamide

There total 15 articles about (S)-3-(5-amino-6-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)pyridin-2-yl)-4-fluoro-N-isopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₈FN₇O₃

: 1214241-26-5
(S)-3-(5-amino-6-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)pyridin-2-yl)-4-fluoro-N-isopropylbenzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1214241-91-4
1-(2-chloro-5-nitropyridin-4-yl)ethanone

: 1214241-26-5
(S)-3-(5-amino-6-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)pyridin-2-yl)-4-fluoro-N-isopropylbenzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid; iron / 4 h

2.1: pyridine / 18 h / 20 °C

2.2: Cooling with ice

3.1: lithium hydroxide / water; tetrahydrofuran; methanol / 15 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 96 h / 110 °C

4.2: 15 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 120 h / 20 °C

7.1: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.33 h / 135 °C / Microwave irradiation

8.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 20 h / 120 °C

9.1: trifluoroacetic acid / dichloromethane

With pyridine; potassium acetate; iron; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 23056-33-9
2-chloro-4-methyl-5-nitro-pyridine

: 1214241-26-5
(S)-3-(5-amino-6-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)pyridin-2-yl)-4-fluoro-N-isopropylbenzamide

Guidance literature:: Multi-step reaction with 13 steps

1.1: N,N-dimethyl-formamide / 18 h / 95 °C

2.1: sodium periodate / water; tetrahydrofuran / 6 h / 20 °C

3.1: titanium tetrachloride / dichloromethane; diethyl ether / 1 h / -78 - -50 °C

3.2: 1 h / -50 °C

4.1: Dess-Martin periodane / dichloromethane / 16 h

5.1: acetic acid; iron / 4 h

6.1: pyridine / 18 h / 20 °C

6.2: Cooling with ice

7.1: lithium hydroxide / water; tetrahydrofuran; methanol / 15 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 96 h / 110 °C

8.2: 15 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h

10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 120 h / 20 °C

11.1: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.33 h / 135 °C / Microwave irradiation

12.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 20 h / 120 °C

13.1: trifluoroacetic acid / dichloromethane

With pyridine; sodium periodate; potassium acetate; titanium tetrachloride; iron; sodium carbonate; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;