methyl 4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-3-methanesulfonylbenzoate

Base Information

• Chemical Name: methyl 4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-3-methanesulfonylbenzoate
• CAS No.: 404963-75-3
• Molecular Formula: C₁₈H₁₆ClNO₆S₃
• Molecular Weight: 473.979
• Mol file: 404963-75-3.mol

Synonyms:methyl 4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-3-methanesulfonylbenzoate

Chemical Property of methyl 4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-3-methanesulfonylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-3-methanesulfonylbenzoate

There total 7 articles about methyl 4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-3-methanesulfonylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride (166964-33-6) + methyl 4-amino-3-methanesulfonylbenzoate (404964-28-9) → methyl 4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-3-methanesulfonylbenzoate (404963-75-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.08.040

Reference yield:

4-chloro-3-(chlorosulfonyl)benzoic acid (2494-79-3) → methyl 4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-3-methanesulfonylbenzoate (404963-75-3)

Guidance literature:

Multi-step reaction with 6 steps

1: aq. NaOH; Na₂SO₃

2: aq. NaOH / methanol

3: 55 percent / 140 °C

4: 100 percent / H₂ / Pd/C / dioxane; methanol

5: 90 percent / aq. H₂SO₄ / Heating

6: NaH / tetrahydrofuran; dimethylformamide

With sodium hydroxide; sulfuric acid; hydrogen; sodium hydride; sodium sulfite; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.08.040

Reference yield:

3-methylsulphonyl-4-chlorobenzoic acid (51522-07-7) → methyl 4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-3-methanesulfonylbenzoate (404963-75-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 55 percent / 140 °C

2: 100 percent / H₂ / Pd/C / dioxane; methanol

3: 90 percent / aq. H₂SO₄ / Heating

4: NaH / tetrahydrofuran; dimethylformamide

With sulfuric acid; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.08.040

upstream raw materials:

5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride

methyl 4-amino-3-methanesulfonylbenzoate

4-chloro-3-(chlorosulfonyl)benzoic acid

3-methylsulphonyl-4-chlorobenzoic acid