1H-Pyrrolo[1,2-a]benzimidazol-3-amine,2,3-dihydro-7-methyl-,(3R)-(9CI)

Base Information

Chemical Name:1H-Pyrrolo[1,2-a]benzimidazol-3-amine,2,3-dihydro-7-methyl-,(3R)-(9CI)
CAS No.:244151-94-8
Molecular Formula:C₁₁H₁₃N₃
Molecular Weight:187.244
Hs Code.:
Mol file:244151-94-8.mol

Synonyms:1H-Pyrrolo[1,2-a]benzimidazol-3-amine,2,3-dihydro-7-methyl-,(3R)-(9CI)

Suppliers and Price of 1H-Pyrrolo[1,2-a]benzimidazol-3-amine,2,3-dihydro-7-methyl-,(3R)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1H-Pyrrolo[1,2-a]benzimidazol-3-amine,2,3-dihydro-7-methyl-,(3R)-(9CI)

Chemical Property:

PSA：43.84000
LogP:2.44850

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[1,2-a]benzimidazol-3-amine,2,3-dihydro-7-methyl-,(3R)-(9CI)

There total 2 articles about 1H-Pyrrolo[1,2-a]benzimidazol-3-amine,2,3-dihydro-7-methyl-,(3R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 244151-91-5
N-(7-methyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-3-yl)-acetamide

: 244151-94-8,244151-84-6
7-methyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-3-ylamine

Guidance literature:: With hydrogenchloride; for 9h; Heating;
DOI:10.1021/jm990029h

Reference yield:

: 244151-81-3,244151-84-6
3-amino-2,3-dihydro-7-methyl-1H-pyrrolo[1,2-a]benzimidazole

: 244151-94-8,244151-84-6
7-methyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-3-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 37 percent / ALTUS 20 CLEC acyltransferase / 0.5 h

2: 95 percent / 1.2 N aq. HCl / 9 h / Heating

With hydrogenchloride; ALTUS 20 CLEC acyltransferase; 1: Acetylation / 2: Deacetylation;
DOI:10.1021/jm990029h

Reference yield:

: 244151-94-8,244151-84-6
7-methyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-3-ylamine

: 244152-36-1
(6-bromo-7-methyl-5-nitro-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-3-yl)-carbamic acid phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / CF₃CO₂H / 0.33 h / 20 °C

2: 85 percent / Br₂; AcOH / 0.33 h / 20 °C

3: 89 percent / HNO₃; Ac₂O / 1.5 h / 20 °C

4: 66 percent / methanol. NH₃ / 48 h / 20 °C

5: 78 percent / pyridine / 1.25 h / 0 - 20 °C

With pyridine; ammonia; bromine; nitric acid; acetic anhydride; acetic acid; trifluoroacetic acid; 1: Acylation / 2: Bromination / 3: Nitration / 4: ammonolysis / 5: Acylation;
DOI:10.1021/jm990029h